Which toxin is heat-labile?
Heat-labile toxin (LT) is a well-characterized powerful enterotoxin produced by enterotoxigenic Escherichia coli (ETEC). This toxin is known to contribute to diarrhea in young children in developing countries, international travelers, as well as many different species of young animals.
How does heat-labile toxin work?
Upon attachment to the epithelium, ETEC release heat-labile (LT) and/or heat-stable enterotoxins, that act upon intestinal enterocytes by disrupting the electrolyte homeostasis, resulting in fluid loss and eventually secretory diarrhea [15].
Where is heat-labile toxin found?
coli heat-labile enterotoxin are located on a large plasmid called pEnt. LT genes share approximately 78% sequence identity with the CT genes of V. cholerae on the nucleotide and amino acid level for preproteins, suggesting that these genes share a common ancestry [186].
What does the heat-labile enterotoxin toxin Cjt cause?
Heat-Labile Enterotoxin-Induced PERK-CHOP Pathway Activation Causes Intestinal Epithelial Cell Apoptosis. Enterotoxigenic Escherichia coli (ETEC) is a leading cause of diarrhea among children and travelers in developing countries, and heat-labile enterotoxin (LT) is one of the most important virulence factors.
What does heat-labile mean?
Destroyed or altered by
adj. Destroyed or altered by heat.
How does ETEC cause diarrhea?
Enterotoxigenic Escherichia coli, or ETEC, is the name given to a group of E. coli that produce special toxins which stimulate the lining of the intestines causing them to secrete excessive fluid, thus producing diarrhea.
Is E. coli heat-labile or stable?
Although heat-stable (ST) and heat-labile (LT) enterotoxins produced by enterotoxigenic Escherichia coli (ETEC) have been documented as important factors associated with diarrheal diseases, investigations assessing the contributions of individual enterotoxins to the pathogenesis of E. coli infection have been limited.
How do you get Enteroaggregative E. coli?
contaminated food – most common way to get a E. coli infection is by eating contaminated food such as ground beef, unpasteurized milk and fresh produce. improper food handling – by consuming raw food, or not cooking the food properly, especially meats and poultry.