What is beta hematin?

What is beta hematin?

β-Hematin is a heme dimer formed via reciprocal covalent bonds between carboxylic acid groups on the protoporphyrin-IX ring and the iron atoms of two heme molecules.

What is the meaning of hematin?

Definition of hematin : a brownish-black or bluish-black derivative C34H33N4O5Fe of oxidized heme also : any of several similar compounds.

How is hematin formed?

During its blood stage, the malaria parasite proteolyzes host hemoglobin in an acidic vacuole to obtain amino acids ( 2), releasing heme as a byproduct which is autoxidized to potentially toxic ( 3) hematin [aquaferriprotoporphyrin IX, H2O-Fe(III)PPIX].

What is hemozoin in malaria?

Hemozoin is a crystalline, brown pigment that is formed and sequestered in the digestive vacuole of Plasmodium as a product of hemoglobin (Hb) catabolism (57). The parasite digests up to 80% of the Hb in the host RBC, which it utilizes as an essential source of nutrients and energy (2).

Is hematin in the blood?

Hematin (Panhematin, Ovation Pharmaceuticals, Deerfield, Ill) contains alkaline heme from processed human red blood cells. It is a lyophilized powder that is best reconstituted in albumin to form a stable solution and minimize thrombophlebitis and anticoagulation.

What is acid hematin method?

The details of these methods are described below. Sahli’s/acid hematin Method. Principle: Blood is mixed with N/10 HCl resulting in the conversion of Hb to acid hematin which is brown in color. The solution is diluted till it’s color matches with the brown colored glass of the comparator box.

What are Ookinetes?

[ ō′ə-kə-nēt′, -kī′nēt′ ] n. The motile zygote of the malarial organism that penetrates the mosquito stomach to form an oocyst under the outer gut lining.

What is Exoerythrocytic cycle?

In the exoerythrocytic stage, sporozoites from the mosquito’s saliva asexually multiply for about 7–28 days in liver cells before differentiating into invasive merozoites which enter the bloodstream to initiate the erythrocytic phase.