What is the treatment for macrocytosis?
Management of macrocytosis consists of finding and treating the underlying cause. In the case of vitamin B-12 or folate deficiency, treatment may include diet modification and dietary supplements or injections. If the underlying cause is resulting in severe anemia, you might need a blood transfusion.
Which drug could be used to help Macrocytic anemias?
Drugs used to treat Anemia, Megaloblastic
| Drug name | Rating | Rx/OTC |
|---|---|---|
| Generic name: leucovorin systemic Drug class: antidotes For consumers: dosage, interactions, side effects For professionals: AHFS DI Monograph, Prescribing Information | ||
| View information about FA-8 FA-8 | Rate | Rx/OTC |
Can metformin cause macrocytosis?
Metformin can cause megaloblastic anemia, due to vitamin B12 deficiency; therefore, we would advise annual blood panels to be required by the prescribing physician for all patients undergoing treatment with metformin.
How does vitamin B12 cause macrocytic anemia?
Vitamin B12 deficiency is a cause of macrocytosis. Because DNA synthesis requires cyanocobalamin (vitamin B12) as a cofactor, a deficiency of the vitamin leads to decreased DNA synthesis in the erythrocyte, thus resulting in macrocytosis.
What are the symptoms of macrocytosis?
Macrocytosis is a term used to describe red blood cells that are larger than normal….Symptoms include:
- loss of appetite or weight.
- brittle nails.
- fast heartbeat.
- diarrhea.
- fatigue.
- pale skin, including lips and eyelids.
- shortness of breath.
- poor concentration or confusion.
Is macrocytosis life threatening?
However, macrocytic anemias can cause long-term complications if left untreated. These complications can include permanent damage to your nervous system. Extreme vitamin B-12 deficiencies may cause long-term neurologic complications. They include peripheral neuropathy and dementia.