What is doxorubicin hydrochloride made from?
Doxorubicin Hydrochloride is the hydrochloride salt of doxorubicin, an anthracycline antibiotic with antineoplastic activity. Doxorubicin, isolated from the bacterium Streptomyces peucetius var. caesius, is the hydroxylated congener of daunorubicin.
What are the properties of doxorubicin?
Doxorubicin is an antineoplastic in the anthracycline class. General properties of drugs in this class include: interaction with DNA in a variety of different ways including intercalation (squeezing between the base pairs), DNA strand breakage and inhibition with the enzyme topoisomerase II.
How is doxorubicin stored?
Store all vials at 2° to 8°C (36° to 46°F). Protect from light. Storage of Doxorubicin Hydrochloride Injection under refrigerated conditions can result in the formation of a gelled product.
Is doxorubicin still used?
Doxorubicin can cause harsh side effects such as heart toxicity (heart failure), severe nausea and vomiting, and total hair loss (alopecia). The brand name product Adriamycin has now been discontinued in the U.S., but the generic doxorubicin is still on the market.
What is doxorubicin hydrochloride used for?
Doxorubicin injection is used together with other medicines to treat cancer of the blood, lymph system, bladder, breast, stomach, lungs, ovaries, thyroid, nerves, kidneys, bones, and soft tissues, including muscles and tendons. It may also be used to treat other kinds of cancer, as determined by your doctor.
How does doxorubicin hydrochloride work?
Doxorubicin is in a class of medications called anthracyclines. It works by slowing or stopping the growth of cancer cells in your body.
How do you dissolve doxorubicin hydrochloride?
For maximum solubility in aqueous buffers, doxorubicin (hydrochloride) should first be dissolved in DMSO and then diluted with the aqueous buffer of choice. Doxorubicin (hydrochloride) has a solubility of approximately 0.5 mg/ml in a 1:1 solution of DMSO:PBS (pH 7.2) using this method.
How much does doxorubicin cost?
The cost for doxorubicin intravenous solution (2 mg/mL) is around $16 for a supply of 5 milliliters, depending on the pharmacy you visit….Intravenous Solution.
| Quantity | Per unit | Price |
|---|---|---|
| 5 milliliters | $3.12 – $3.97 | $15.62 – $19.85 |
| 10 milliliters | $2.07 – $3.60 | $20.72 – $36.02 |
How is doxorubicin hydrochloride administered?
Doxorubicin is administered intravenously and intravesically and must not be administered orally, subcutaneously, intramuscularly or intrathecally. Doxorubicin can be administered intravenously as bolus within minutes, as short infusion for up to an hour or as continuous infusion for up to 96 hours.