What is T cell independent antigen?
T-independent (TI) antigens are typically polysaccharides with the ability to induce B-cell proliferation and antibody secretion in the absence of T cells.
What does T cell independent mean?
Antibody production independent of T lymphocytes The non-protein microbial antigens cannot stimulate classical T cell response by themselves, but they are able to elicit the production of antibodies, so that is why we call them T cell or thymus independent antigens.
What is the difference between T dependent and T-independent antigens?
T-dependent antigens can stimulate B cells to become activated but require cytokine assistance delivered by helper T cells. T-independent antigens can stimulate B cells to become activated and secrete antibodies without assistance from helper T cells.
Where are T-lymphocytes formed?
bone marrow
T lymphocytes develop from a common lymphoid progenitor in the bone marrow that also gives rise to B lymphocytes, but those progeny destined to give rise to T cells leave the bone marrow and migrate to the thymus (see Fig. 7.2). This is the reason they are called thymus-dependent (T) lymphocytes or T cells.
How are T-lymphocytes activated?
T-lymphocyte activation requires recognition of a specific antigen carried by an antigen-presenting cell, and a second co-stimulatory signal. A major co-stimulatory signal involves binding of CD80 and CD86 molecules on the surface of antigen-presenting cells to the CD28 receptor on T-cells.
How are T dependent antigens different from T independent antigens quizlet?
How do T-independent antigens differ from T-dependent antigens? T-independent antigens (lipopolysaccharide and polysaccharides that have numerous identical epitopes) can activate B cells in the absence of T-cell assistance, while T-dependent antigens (proteins) require this T-cell assistance).
Which of the following would be a T dependent antigen?
Thymus-dependent antigens include proteins, polypeptides, hapten-carrier complexes, erythrocytes, and many other antigens that have diverse epitopes. T dependent antigens contain some epitopes that T cells recognize and others that B cells identify.