Can hydroxychloroquine cause pancytopenia?

Can hydroxychloroquine cause pancytopenia?

Hydroxychloroquine, an antimalarial drug that is used in RA and SLE, can also cause pancytopenia and hemolysis in glucose-6-phosphatase deficiency (G6PD) patients and should be avoided in such patients. Close monitoring of blood counts and decreasing the medication doses is helpful in preventing pancytopenia.

Can plaquenil cause anemia?

Rarely, hydroxychloroquine can affect the bone marrow leading to reduced white blood cells (leukopenia) or platelets (thrombocytopenia) and abnormal red blood cells (anemia). Rare but potentially serious eye toxicity can occur.

What drugs can cause pancytopenia?

chemotherapy treatments, including methotrexate, carbamazepine, and chloramphenicol. certain medications, such as trimethoprim-sulfamethoxazole (Bactrim) toxicity from drugs or chemotherapy agents. inherited conditions, such as Fanconi’s anemia.

Does plaquenil cause thrombocytopenia?

Hydroxychloroquine is used in the long-term therapy of systemic lupus erythematosus (SLE). Although considered to be a safe treatment, side effects have been documented. An uncommon side effect is thrombocytopenia.

Does Plaquenil affect blood test results?

Hydroxychloroquine overdose can cause hypokalemia. Hydroxychloroquine overdose can result in electrocardiographic abnormalities. Hydroxychloroquine can interfere with urine chemistry and drug screening assays.

Does lupus cause pancytopenia?

Pancytopenia. It may results from bone marrow failure, such as in the case of aplastic anemia. Macrophage activation syndrome, although unusual has been reported in SLE.

Does hydroxychloroquine lower blood platelets?

Hydroxychloroquine Reduces Platelet Activity, Improves Vascular Health in Systemic Lupus Erythematosus. Platelet dense granule membrane and positive regulation of platelet activation significantly negatively correlated with hydroxychloroquine dose and weight.

What type of anemia has pancytopenia?

Megaloblastic anemia was considered the most common cause of Pancytopenia (41.9%) in our study. Similar results have been found by other local studies. The diagnosis of Megaloblastic anemia in our study was established by characteristic bone marrow findings.

Is pancytopenia a type of anemia?

Pancytopenia occurs when you have a combination of three different blood disorders: Anemia is when you have too few red blood cells. Leukopenia is when you have too few white blood cells. Thrombocytopenia is when you have too few platelets.

Can Plaquenil cause neutropenia?

Discussion: Hydroxychloroquine has relative safety profile with 0.73% incidence of neutropenia. Though there are some case reports of its use to treat neutropenia in some condition like Felty’s syndrome(1), this is the first reported case of profound neutropenia to the best of our knowledge.

How do you know if plaquenil is working?

Plaquenil works very slowly. In 1 to 3 months you should start to feel better. You may continue to get better for up to 1 year. Most people who take Plaquenil also take other medicines for pain and stiffness.

Does hydroxychloroquine affect creatinine levels?

A small retrospective study on 118 patients with rheumatoid arthritis reported that 55% of patients receiving chloroquine and 15% of those receiving hydroxychloroquine showed a >10% decrease of creatinine clearance after the start of antimalarial drugs (8).