What is the major function of apoB-48?
ApoB48 is identical to the amino-terminal 48% of ApoB100. The function of this isoform is in fat absorption of the small intestine and is involved in the synthesis, assembly and secretion of chylomicrons.
What is the function of the apoB protein?
Apolipoprotein B-100 allows LDLs to attach to specific receptors on the surface of cells, particularly in the liver. Once attached, the receptors transport LDLs into the cell, where they are broken down to release cholesterol. The cholesterol is then used by the cell, stored, or removed from the body.
In which of following apo B-48 is present?
Apolipoprotein B-48 (apoB-48) is known to be the only specific marker of intestinal chylomicron particles. The amino acid sequence of apoB-48 represents 48% of the initial sequence of apoB-100. ApoB-48 is synthesized only by the intestine in humans, while apoB-100 is synthesized primarily by the liver.
How is apo b48 formed?
The production of apoB48, the N-terminal 2152 amino acids (48%) of apoB100 (Fig 1), results from RNA editing by an enterocyte enzyme which introduces a premature stop codon in the coding region for apoB100 [27, 28].
Do Statins lower apoB?
Statins inhibit cholesterol synthesis and activate LDL receptor, thus decreasing the levels in LDL-C and apo B, among which, apo B is a vehicle and a ligand for transporting and degrading endogenous cholesterol synthesized in liver (25,26).
Why is ApoB100 important?
ApoB100 has a central role in the development of atherosclerosis. Two proteoglycan-binding sequences in apoB100 have been identified, which are important for retaining the lipoprotein in the intima of the artery. Retention is essential for the development of the atherosclerotic lesion.
Do Statins lower ApoB?
What is a normal ApoB level?
Results are given in milligrams per deciliter (mg/dL). Normal levels of ApoB-100 in adults are less than 100 mg/dL. Your risk is high if you have a result greater than 110 mg/dL. High levels of ApoB may mean that you have a higher than normal risk of developing cardiovascular disease.
What are the apoB remnants?
These atherogenic lipoproteins comprise chylomicron remnants, very-low-density lipoprotein (VLDL), intermediate-density lipoprotein, LDL, and lipoprotein(a). ApoB is a large protein that envelops the surface of atherogenic lipoproteins as a macromolecular scaffold to provide structural integrity.
What does high apoB mean?
What does the test result mean? Elevated levels of apo B correspond to elevated levels of LDL-C and to non-HDL-C and are associated with an increased risk of cardiovascular disease (CVD). Elevations may be due to a high-fat diet and/or decreased clearing of LDL from the blood.
What is apolipoprotein b48?
Apolipoprotein B-48 (apoB-48) is known to be the only specific marker of intestinal chy lomicron particles. The amino acid sequence of apoB-48 represents 48% of the initial sequence of apoB-100. ApoB-48 is synthesized only by the intestine in humans, while apoB-100 is synthesized primarily by the liver.
How do you reduce apoB?
How To Lower ApoBs. Consuming less dietary fat and cholesterol and many more fiber-rich, whole plant foods, which is essentially the Pritikin Eating Plan, will greatly reduce the amount of chylomicrons and their atherogenic, apoB-48-containing lipoproteins in the blood.
What is apob-48?
ApoB-48 is an apolipoprotein specific to a lipoprotein, chylomicron (CM) which is formed in intestine and carries exogenous lipids derived from foods to the liver and peripheral tissues. Measurement of ApoB-48 is useful in observation and pursuit of postprandial dynamics of lipoprotein, lipid-soluble nutrients and drugs．
What is apolipoprotein B-48?
Apolipoprotein-B48 (ApoB-48) has 48% amino acid sequence of apolipoprotein B-100 which is present in lipoproteins ,VLDL, LDL and HDL of liver origin. ApoB-48 is an apolipoprotein specific to a lipoprotein, chylomicron (CM) which is formed in intestine and carries exogenous lipids derived from foods to the liver and peripheral tissues.
What is Apo B-48 VLDL?
defined apo B-48 VLDL as the subfraction of parti- cles isolated from fasting subjects at d < 1.006 g/ml that are not retained on the anti-apo B-100 immuno- adsorbants, and apo B-100 VLDL as the subfraction f.or 0.5 o CD C D 1.0 0.5 1.0 0.5 NON-RETAINED FRACTION 0.1 1 PROTEIN (tig/ml) 10 100 Figure 2. Type IV VLDL (5 mg) was passed on 5E11
Is Apo B-48 a good marker of lipid transport?
Since one role of CM is to transfer exogenous lipids derived from food to the liver or peripheral tissues, the measurement of Apo B-48 is considered a best marker for observation of exogenous lipid transportation after food intake.