What is the IL-23 IL-17 Axis?
The IL-23/IL-17 axis plays an important role in the development of chronic inflammation and in host defenses against bacterial infection. (A) In chronic inflammation, antigen-stimulated dendritic cells and macrophages produce IL-23, which promotes the development of Th17/ThIL-17 cells.
Is IL-17 pro or anti inflammatory?
Our results show that IL-17 has anti-inflammatory activity and that this cytokine can suppress the development of autoimmune disease. Recent studies have identified an autoreactive T cell subset that produces IL-17, but not IFN-γ and IL-4 (1, 2).
What are some cytokines associated with the IL-17 pathway?
IL-17 induces the production of many other cytokines (such as IL-6, G-CSF, GM-CSF, IL-1β, TGF-β, TNF-α), chemokines (including IL-8, GRO-α, and MCP-1), and prostaglandins (e.g., PGE2) from many cell types (fibroblasts, endothelial cells, epithelial cells, keratinocytes, and macrophages).
What is the function of IL-23?
IL-23 functions in innate and adaptive immunity, and is a key cytokine for promoting inflammatory responses in a variety of target organs. The most important function ascribed to IL-23 is its role in the development and differentiation of effector Th17 cells via activation of STAT3.
How does IL-17RC interact with ACT1?
We further found that IL-17RC interacts directly with the adaptor/E3 ubiquitin ligase Act1, and that the functional IL-17RC isoforms containing the extended SEFIR region interact specifically with a phosphorylated isoform of Act1.
What does the interleukin-17 (IL-17) cytokine family do?
The interleukin (IL)-17 cytokine family members IL-17A and IL-17F mediate inflammatory activities via the IL-17 receptor (IL-17R) complex, comprised of the IL-17RA and IL-17RC subunits. Proper regulation of the IL-17 signaling axis results in effective host defense against extracellular pathogens, w …
What is the role of il-17a-il-17f in downstream signaling?
IL-17 mediates essential inflammatory responses in host defense and autoimmunity. The IL-17A-IL-17F signaling complex is composed of IL-17RA and IL-17RC, both of which are necessary for signal transduction. To date, the specific contribution of IL-17RC to downstream signaling remains poorly understood.
What is the function of interleukin 17A and 17F?
The interleukin (IL)-17 cytokine family members IL-17A and IL-17F mediate inflammatory activities via the IL-17 receptor (IL-17R) complex, comprised of the IL-17RA and IL-17RC subunits.