What is HTR1B gene?
HTR1B (5-Hydroxytryptamine Receptor 1B) is a Protein Coding gene. Diseases associated with HTR1B include Obsessive-Compulsive Disorder and Personality Disorder. Among its related pathways are Peptide ligand-binding receptors and Monoamine GPCRs.
What does 5-HT1B do?
5-HT1B receptors inhibit the release of a range of neurotransmitters, including serotonin, GABA, acetylcholine, and glutamate. These receptors have been difficult to study because of the diversity of their cellular localization and the absence of highly selective agonists and antagonists.
Where are 5ht1b receptors located?
5-HT1B receptors are expressed throughout the mammalian central nervous system. These receptors are located on the axon terminals of both serotonergic and nonserotonergic neurons, where they act as inhibitory autoreceptors or heteroreceptors, respectively.
What drug binds to serotonin receptors?
Serotonin Receptor Agonists
| Drug | Drug Description |
|---|---|
| Eletriptan | A triptan used for the treatment of migraines. |
| Zolmitriptan | A member of the triptan class of 5-HT(1B/1D/1F) receptor agonist drugs used for the acute treatment of migraine with or without aura in adults. |
| Lisuride | For the management of Parkinson’s Disease |
How do triptans cause vasoconstriction?
In conclusion, triptans induce vasoconstriction in arteries and veins from the thoracic wall, most likely by activation of 5-HT1B receptors.
Can too much serotonin cause anxiety?
It has long been suggested that over-activity of the serotonin system may relate to mood disorders such as depression and anxiety, as these seem characterized by too much withdrawal and avoidance.
How do I know if I have low serotonin?
Mental health symptoms People who feel unusually irritable or down for no apparent reason may have low serotonin levels. Depression: Feelings of sadness, hopelessness, and anger, as well as chronic fatigue and thoughts of suicide, may indicate depression. Anxiety: Low serotonin levels may cause anxiety.
What is the HTR1B gene?
HTR1B 5-hydroxytryptamine receptor 1B [ (human)] Summary. The protein encoded by this intronless gene is a G-protein coupled receptor for serotonin (5-hydroxytryptamine). Ligand binding activates second messengers that inhibit the activity of adenylate cyclase and manage the release of serotonin, dopamine, and acetylcholine in the brain.
Where can I find information about the 5-HT1B receptor?
“5-HT 1B “. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Human HTR1B genome location and HTR1B gene details page in the UCSC Genome Browser. Overview of all the structural information available in the PDB for UniProt: P28222 (5-hydroxytryptamine receptor 1B) at the PDBe-KB.
What is the IUPHAR PMID for HTR1B?
PMID 12898580. S2CID 33460360. “5-HT 1B “. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Human HTR1B genome location and HTR1B gene details page in the UCSC Genome Browser.
Does P11 Express HTR1B?
Data indicate that most p11 expressing cells in cerebral cortex, hippocampus, cerebellum, & caudate-putamen express HTR1B or co-express HTR1B/HTR4, suggesting crucial role for p11 in modulating actions of serotonin via these receptor subtypes.