What is ERG in cancer?
TMPRSS2-ERG is a high-frequency fusion gene expressed in prostate cancer and plays a vital role in carcinogenesis. Recent studies showed that TMPRSS2-ERG is a potential predictive biomarker for prostate cancer.
What does ERG positive mean?
Positive staining – normal. Both blood vessel and lymphatic endothelial cells. Subpopulation of immature myeloid cells in an adult bone marrow. Early embryonic subepidermal and paraspinal mesenchyme and periphery of cartilage (Am J Surg Pathol 2011;35:432)
What is ERG overexpression?
INTRODUCTION. ERG overexpression resulting from the rearrangement between the TMPRSS2 promoter and the coding regions of the ERG gene has been identified as the most common alteration in prostate cancer (PrCa), accounting for more than 90% of the TMPRSS2-ETS family rearrangements [1–3].
What is exon 7b?
Exon 7 encodes 27 amino acids and exon 7b encodes 24 amino acids, both in frame. These extra amino acids are added to the transcriptional activation domain (TAD) thought to influence the interaction of ERG with protein partners involved in transcriptional regulation [4].
What is ERG in cells?
ETS-related gene (ERG) is a member of the E-26 transformation-specific (ETS) family of transcription factors with roles in development that include vasculogenesis, angiogenesis, haematopoiesis and bone development. ERG’s oncogenic potential is well known because of its involvement in Ewing’s sarcoma and leukaemia.
What is ERG oncogene?
ERG (ETS-related gene) is an oncogene. ERG is a member of the ETS (erythroblast transformation-specific) family of transcription factors. The ERG gene encodes for a protein, also called ERG, that functions as a transcriptional regulator.
What is ERG in pathology?
ERG, a member of the ETS family of transcription factors, is a highly specific endothelial marker. We investigated whether the use of ERG immunostaining can help pathologists detect lymphovascular invasion (LVI) and decrease interobserver variability in LVI diagnosis.
What is the full form of ERG?
ERG stands for employee resource group. Other lesser used terms include affinity groups or business networking groups. Current groups offer much more than mere professional networking opportunities.
How is an ERG performed?
During an ERG recording session, the patient looks into a bowl displaying different amounts of light. Retinal cells emit small electrical signals when stimulated by certain types of light. The ERG machine records the resulting electric signals’ amplitude (voltage) and time course.
What is ERG marker?
On the basis of the above observations, ERG is a highly specific new marker for benign and malignant vascular tumors. Among epithelial tumors, ERG shows a great promise as a marker to identify prostatic carcinoma in both primary and metastatic settings.
What is ERG in biology?
How is an erg performed?
As in full field ERG the patient assumes a comfortable seated position. Usually the patient’s eyes are dilated beforehand with standard dilating eye drops. The technician will place a numbing drop in the eye. The patient is asked to look up, and an electrode is gently placed on the eye.
What is the ERG gene?
ERG (ETS Transcription Factor ERG) is a Protein Coding gene. Diseases associated with ERG include Extraskeletal Ewing Sarcoma and Ewing Sarcoma . Among its related pathways are TarBasePathway and Endometrial cancer .
What is ERG ETS transcription factor?
ERG ETS transcription factor ERG [] Summary. This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis.
What is the effect of circrna_103993 on ERG gene regulation?
Effects of circRNA_103993 on the proliferation and apoptosis of NSCLC cells through miR-1271/ERG signaling pathway. A non-coding genetic variant associated with abdominal aortic aneurysm alters ERG gene regulation. Detection of TMPRSS2-ERG Fusion Transcript in Biopsy Specimen of Prostate Cancer Patients: A Single Centre Experience.
What is the role of Erg in prostate cancer?
KPNA2/ERG Coexpression is Associated With Early Recurrence in Advanced Prostate Cancers. Oncogenic ERG Represses PI3K Signaling through Downregulation of IRS2. ERG Controls B Cell Development by Promoting Igh V-to-DJ Recombination.