What is 16 Hydroxy?
16α-Hydroxyestrone (16α-OH-E1), or hydroxyestrone, also known as estra-1,3,5(10)-triene-3,16α-diol-17-one, is an endogenous steroidal estrogen and a major metabolite of estrone, as well as an intermediate in the biosynthesis of estriol.
What does Asassn-16oh stand for?
All-Sky Automated Survey for Supernovae
However, ASASSN-16oh shows there is more to the story. This binary was first discovered by the All-Sky Automated Survey for Supernovae (ASASSN), a collection of about 20 optical telescopes distributed around the globe to automatically survey the entire sky every night for supernovas and other transient events.
What are estrogen metabolites?
Estrogen metabolism occurs when estrone and estradiol, the parent estrogens, are irreversibly hydroxylated at the 2-, 4-, or 16-position of the steroid ring ( Figure 1 ), producing 13 known estrogen metabolites.
What is 16 OH E1?
16-OH-E1 is the immediate precursor to the weak estrogen, estriol (E3). Please also note that 16-OH-E1 is important for maintaining bone mineral density. Excessive reduction of 16-OH-E1 may reduce bone formation and increase oxidant stress.
How does estrone differ from estradiol?
Estrone is an estrogen, specifically an agonist of the estrogen receptors ERα and ERβ. It is a far less potent estrogen than is estradiol, and as such, is a relatively weak estrogen. Given by subcutaneous injection in mice, estradiol is about 10-fold more potent than estrone and about 100-fold more potent than estriol.
How does your body metabolize estrogen?
Estrogens are eliminated from the body by metabolic conversion to estrogenically inactive metabolites that are excreted in the urine and/or feces. The first step in the metabolism of estrogens is the hydroxylation catalyzed by cytochrome P450 (CYP) enzymes.
Is estrogen excreted in urine?
Over 40% of estradiol excreted in the urine is converted to estrone, and the major portion is in the form of a polar conjugate that is presently not detectable by RIA. Over 85% of estradiol is excreted in the urine.
What causes high e1?
Because estrone forms in fatty tissue, obesity can lead to more estrone production. Other causes of high estrone may include: Breast cancer. Treatment to reduce testosterone, such as prostate cancer treatment.
What happens if estrogen is too high?
Summary. High estrogen levels can cause symptoms such as irregular or heavy periods, weight gain, fatigue, and fibroids in females. In males, they can cause breast tissue growth, difficulty getting or maintaining an erection, and infertility.
What is 16-oh-e1?
16-OH-E1 is the immediate precursor to the weak estrogen, estriol (E3). Please also note that 16-OH-E1 is important for maintaining bone mineral density. Excessive reduction of 16-OH-E1 may reduce bone formation and increase oxidant stress.
What is asassn-16oh?
ASASSN-16oh is a peculiar transient supersoft X-ray source without a mass-ejection signature in the field of the Small Magellanic Cloud. Maccarone et al. concluded that ASASSN-16oh is the first dwarf nova with supersoft X-ray that originated from an equatorial accretion belt on a white dwarf (WD).
What is 16α-Hydroxyestrone (16α-OH-E1)?
Phase 2 is a reduction phase that produces Estriol which is a weak estrogen. 16α-Hydroxyestrone (16α-OH-E1), or hydroxyestrone, also known as estra-1,3,5 (10)-trien-3,16α-diol-17-one, is an endogenous steroidal estrogen and a major metabolite of estrone, as well as an intermediate in the biosynthesis of estriol.
Is 16-oh-e1 a methylated estrogen?
Only 2-OH and 4-OH estrogens are methylated. 16-OH-E1 is not. – A moderately potent estrogen. Binds primarily to Estrogen Receptor Alpha (ERα). – Estrone is metabolized into 2-OH E1 (“good”), 16-OH-E1 (“bad”), and 4-OH-E1 (“bad”).
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