What causes overexpression of BCL-2?

What causes overexpression of BCL-2?

The results suggest that gene amplification and translocation are at least equally common mechanisms causing bcl-2 protein overexpression in DLBCL. Bcl-2 protein overexpression as determined by IHC is associated with poor response to chemotherapy and poor survival.

How does BCL-2 overexpression lead to Tumour progression?

Bcl-2 is widely believed to be an apoptosis suppressor gene. Overexpression of the protein in cancer cells may block or delay onset of apoptosis, by selecting and maintaining long-living cells and arresting cells in the G0 phase of the cell cycle.

What does the BCL-2 gene do?

Bcl-2 (B-cell lymphoma 2), encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins that regulate cell death (apoptosis), by either inhibiting (anti-apoptotic) or inducing (pro-apoptotic) apoptosis. It was the first apoptosis regulator identified in any organism.

How does BCL-2 cause cancer?

A role for Bcl2 in cancer was first identified more than 20 years ago in follicular lymphoma, where it is involved in the t(14;18) chromosome translocation, placing Bcl2 under the control of the immunoglobulin heavy-chain promoter resulting in its deregulated high level of expression [9, 10].

What is the importance of the protein Bcl-2 in apoptosis?

The BCL-2 family of proteins controls cell death primarily by direct binding interactions that regulate mitochondrial outer membrane permeabilization (MOMP) leading to the irreversible release of intermembrane space proteins, subsequent caspase activation and apoptosis.

How does bcl-2 prevent apoptosis?

Bcl-2 inhibits apoptosis by increasing the time-to-death and intrinsic cell-to-cell variations in the mitochondrial pathway of cell death. Apoptosis.

What is the importance of the protein bcl-2 in apoptosis?

What is the importance of the protein BCL-2 in apoptosis?

How does BCL-2 prevent apoptosis?