Is penicillin G narrow-spectrum?
While penicillin G is a narrow-spectrum antibiotic, it is reliably active against many gram-positive pathogens that cause IE, most notably streptococci and enterococci. Penicillin G resistance may occur in streptococci and enterococci through alterations in the PBPs that decrease the binding affinity of penicillin.
Why is potassium added to penicillin G?
Penicillin G potassium binds to penicillin binding proteins (PBP), the enzymes that catalyze the synthesis of peptidoglycan, which is a critical component of the bacterial cell wall. This leads to the interruption of cell wall synthesis, consequently leading to bacterial cell growth inhibition and cell lysis.
Can you give penicillin G potassium?
Penicillin G potassium is injected into a muscle or into a vein through an IV. You may be shown how to use an injection at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles, IV tubing, and other items used to inject the medicine.
Is penicillin G considered broad-spectrum?
Penicillin G is a broad-spectrum, beta-lactam naturally occurring penicillin antibiotic with antibacterial activity. Penicillin G binds to and inactivates the penicillin binding proteins (PBPs) located inside the bacterial cell wall.
Why is penicillin called a narrow-spectrum antibiotic?
Because they target very specific bacteria, they don’t cause an increase in bacterial restistance and avoid the spread of drug resistant infections.
Why is penicillin considered a narrow-spectrum antibiotic?
Narrow-spectrum antibiotic allow to kill or inhibit only those bacteria species that are unwanted (i.e. causing disease). As such, it leaves most of the beneficial bacteria unaffected, hence minimizing the collateral damage on the microbiota. Low propensity for bacterial resistance development.
How much potassium is in penicillin G potassium?
Penicillin G Potassium Injection, USP contains 1.7 mEq potassium and 1.02 mEq of sodium per million units.
What is the difference between penicillin G potassium and penicillin G sodium?
Penicillin G Sodium is generally used in patients who cannot tolerate Penicillin G Potassium (e.g., patients with renal impairment). Most patients requiring parenteral penicillin therapy can tolerate Penicillin G Potassium, of which there is no shortage.
Can penicillin cause high potassium?
Hypokalemia and Hyperkalemia High potassium intake (e.g., oral potassium replacement, total parenteral nutrition, and high-dose potassium penicillin) can cause hyperkalemia, usually in the setting of low renal potassium excretion.
What are the example of narrow-spectrum antibiotics?
Examples of narrow-spectrum antibiotics are the older penicillins (penG), the macrolides and vancomycin. Examples of broad-spectrum antibiotics are the aminoglycosides, the 2nd and 3rd generation cephalosporins, the quinolones and some synthetic penicillins.
What are narrow-spectrum antibiotics used for?
Narrow spectrum antibiotics are used for the specific infection when the causative organism is known. They will not kill as many of the normal micro organisms in the body as the broad spectrum antibiotics.