Is indole a compound?
Indoles are compounds containing a benzene ring fused to a five-membered nitrogen containing pyrrole ring.
Which drug is under the chemical class of indole?
best-known indole-containing compounds are the indole alkaloids, which have been isolated from plants representing more than 30 families. The mushroom hallucinogens psilocin and psilocybin, the ergot fungus alkaloids, the drugs reserpine and yohimbine, and the poison strychnine all belong to this group.
What is indole used for?
Indole-3-carbinol is used for prevention of breast cancer, colon cancer, and other types of cancer. The National Institutes of Health (NIH) has reviewed indole-3-carbinol as a possible cancer preventive agent and is now sponsoring clinical research for breast cancer prevention.
What is indole production?
Indole is generated by reductive deamination from tryptophan via the intermediate molecule indolepyruvic acid. Tryptophanase catalyzes the deamination reaction, during which the amine (-NH2) group of the tryptophan molecule is removed. Final products of the reaction are indole, pyruvic acid, ammonium (NH4+) and energy.
What are indole alkaloids used for?
Since ancient times, plants containing indole alkaloids have been used as psychedelic drugs. The Aztecs used and the Mazatec people continue to use psilocybin mushrooms and the psychoactive seeds of morning glory species like Ipomoea tricolor.
What is indole in microbiology?
Indole is an intercellular signal in both gram-positive and gram-negative bacteria and has been shown to control a number of bacterial processes such as spore formation, plasmid stability, drug resistance, biofilm formation, and virulence (Lee & Lee, 2010). From: Advances in Applied Microbiology, 2014.
What is indole production in microbiology?
What is an example of indole alkaloids?
Two plants that contain indole alkaloids are Passiflora incarnata L. (passion flower) and Mitragyna speciosa (Korth.) Havil (kratom), while the other two plants that did not show the presence of indole alkaloids are Piper methysticum G. Forst (kava) and Valeriana officinalis L., deserve special attention.
What is the chemical name of indole?
From Wikipedia, the free encyclopedia Indole is an aromatic heterocyclic organic compound with formula C 8 H 7 N. It has a bicyclic structure, consisting of a six-membered benzene ring fused to a five-membered pyrrole ring. Indole is widely distributed in the natural environment and can be produced by a variety of bacteria.
What are some examples of indolic compounds?
Other indolic compounds include the plant hormone auxin (indolyl-3-acetic acid, IAA ), tryptophol, the anti-inflammatory drug indomethacin, and the betablocker pindolol . The name indole is a portmanteau of the words ind igo and ole um, since indole was first isolated by treatment of the indigo dye with oleum.
What is the role of indole in the human body?
A number of indole derivatives have important cellular functions, including neurotransmitters such as serotonin. This diagram shows the biosynthesis of bioactive compounds (indole and certain other derivatives) from tryptophan by bacteria in the gut. Indole is produced from tryptophan by bacteria that express tryptophanase.
What is the structure of 1H indole?
1H-indole is an indole and a polycyclic heteroarene. It has a role as an Escherichia coli metabolite. It is a tautomer of a 3H-indole. Indole is an aromatic heterocyclic organic compound. It has a bicyclic structure, consisting of a six-membered benzene ring fused to a five-membered nitrogen-containing pyrrole ring.