How do you give gentamicin IV?

How do you give gentamicin IV?

Gentamicin when given intravenously should be injected directly into a vein or into the drip set tubing over no less than three minutes. If administered by infusion, this should be over no longer than 20 minutes and in no greater volume of fluid than 100ml.

How do you calculate gentamicin?

The dose is calculated using these assumptions:

1. CrCl > 40ml/min at 5mg/kg dose to a maximum of 500mg.
2. CrCl 10-40ml/min at 3mg/kg dose to a maximum of 300mg.
3. CrCl <10ml/min at 1mg/kg dose to a maximum of 120mg.
4. Round the dose up or down to the nearest 20mg increment for doses less than 200mg and 40mg above this.

What is gentamicin dosing?

Renally adjusted dose recomendations are based on doses of 1.7 mg/kg/dose q8hr or 5-7 mg/kg/dose once daily. CrCl>50 mL/min: No dosage adjustment necessary. CrCl 10-50 mL/min: Administer q12-48 hr. CrCl<10 mL/min: Administer q48-72 hr.

How often is IV gentamicin given?

2.5 mg/kg/dose IV or IM every 12 hours. The FDA-approved dose is 2.5 mg/kg/dose IV or IM every 8 hours. 2.5 mg/kg/dose IV or IM every 18 hours. The FDA-approved dose is 2.5 mg/kg/dose IV or IM every 12 hours.

How do you dilute gentamicin IM?

For intermittent intravenous administration in adults, a single-dose of gentamicin sulfate may be diluted in 50 to 200 mL of sterile isotonic saline solution or in a sterile solution of 5% dextrose in water, in infants and children, the volume of diluent should be less.

Why is gentamicin given once daily?

Although administration of multiple daily doses remains the standard method of aminoglycoside dosing, once-daily dosing may provide enhanced clinical efficacy and reduced toxicity in selected patient populations; demonstrated pharmacokinetic and pharmacodynamic advantages include enhanced postantibiotic effect and an …

When should gentamicin levels be measured?

Gentamicin levels should be taken 6-14 hours after the start of the infusion. For a daily dose of 5mg/kg/day the Urban-Craig nomogram can be used. Gentamicin levels should be taken 8-12 hours after the dose.

How is gentamicin calculated for kids?

Dosage For Patients With Normal Renal Function Children: 6 to 7.5 mg/kg/day. (2 to 2.5 mg/kg administered every 8 hours.) Infants and Neonates: 7.5 mg/kg/day. (2.5 mg/kg administered every 8 hours.)

Where do you inject gentamicin IM?

This medicine is given as a shot into a muscle or into a vein. To help clear up your infection completely, keep using this medicine for the full time of treatment, even if you begin to feel better after a few days.

How do you make gentamicin solution?

Gentamicin (20 mL) For a stock solution of 7.5 mg/mL: 150 mg Gentamicin. 20 mL ddH2O. Filter sterilize.

How are aminoglycosides dosed?

The traditional approach to parenteral aminoglycoside dosing in adults involves the administration of a weight-based dose divided two to three times daily in patients with normal renal function.