How do you administer citicoline?
Adult: 500-1,000 mg daily given via IM inj or slow IV inj over 3-5 minutes, or infused at a rate of 40-60 drops/minute. Adult: As tab: 500 mg once daily or bid, or 1,000 mg once daily. As solution: 100-200 mg bid or tid. May be taken with or without food.
What class of drug is citicoline?
This compound belongs to the class of organic compounds known as pyrimidine ribonucleoside diphosphates. These are pyrimidine ribonucleotides with diphosphate group linked to the ribose moiety.
What is the mechanism of action of citicoline?
Citicoline increases phosphatidylcholine synthesis. The mechanism for this may be: By converting 1, 2-diacylglycerol into phosphatidylcholine. Stimulating the synthesis of SAMe, which aids in membrane stabilization and reduces levels of arachidonic acid.
What is citicoline found in?
CLA is in many animal products, like milk, beef, and other meat. Grass-fed beef may have higher levels of CLA than grain-fed beef. It’s also in sunflower and safflower oil. Cooking food may increase levels of CLA.
Where is citicoline from?
Citicoline has an oral bioavailability of approximately 92 percent. It’s first broken down in the small intestines and liver to cytidine and choline. Cytidine is then metabolized into uridine.
Is phosphatidylcholine the SAMe as citicoline?
CDP-choline is a naturally occurring compound produced by the body. It is a precursor in the synthesis of phosphatidylcholine, a major component of biological membrane. The pharmaceutical version (i.e. exogenous CDP-choline) is called citicoline.
Is citicoline the same as phosphatidylcholine?
Is choline the same as phosphatidylcholine?
Overview. Phosphatidylcholine is a chemical contained in eggs, soybeans, mustard, sunflower, and other foods. The term “phosphatidylcholine” is sometimes used interchangeably with “lecithin,” although the two are different. Choline is a component of phosphatidylcholine, which is a component of lecithin.