What type of protein is tubulin?
Tubulin, a globular polypeptide of 50-55 K daltons, is an important protein of the cytoskeleton and mitotic spindle of all living cells. The most abundant source of tubulin is the brain of vertebrates.
What is tubulin protein made of?
Microtubules are the largest type of filament, with a diameter of about 25 nanometers (nm), and they are composed of a protein called tubulin. Actin filaments are the smallest type, with a diameter of only about 6 nm, and they are made of a protein called actin.
Is tubulin a structural protein?
Microtubules. Structural support, intracellular support, and DNA segregation are provided to eukaryotic cells by α- and β-tubulin, polymerized into microtubules. These structures are formed of rigid hollow, fibrous shafts of the globular protein, tubulin, that measure around 25 nm in diameter.
What is the structure of tubulin?
Our model of tubulin shows a compact molecular structure with three functional domains: namely, GTP-binding, drug-binding and motor/MAP-binding domains. The interaction between domains is very tight, so the effects that nucleotides, drugs and other proteins in the cell have on tubulin are firmly linked.
What is the function of protein tubulin?
Tubulin is the protein that polymerizes into long chains or filaments that form microtubules, hollow fibers which serve as a skeletal system for living cells. Microtubules have the ability to shift through various formations which is what enables a cell to undergo mitosis or to regulate intracellular transport.
What is the function of the tubulin?
What phase is tubulin protein synthesis?
In the G2 phase synthesis of tubulin protein which is the major component of microtubules takes place.
In what period of the cell cycle does tubulin protein synthesis occur?
alpha 1-, alpha 2-, beta 1-, and beta 2-tubulin synthesis increases coordinately until metaphase, and then falls, with beta 2 falling more rapidly than beta 1. Nucleic acid hybridization demonstrated that alpha- and beta-tubulin RNAs accumulate coordinately during G2, peaking at metaphase.