What is the mechanism of action of calcipotriol?
Calcipotriol acts like vitamin D. It is antiproliferative, reducing the abnormal proliferation of keratinocytes that occurs in psoriasis, and it induces cell differentiation, normalising epidermal growth.
How does calcipotriol work for psoriasis?
Calcipotriol, a vitamin D3 analog, acts not only to inhibit cell proliferation and enhance cell differentiation in the skin of patients with psoriasis, but also appears to have effects on immunologic markers that are thought to play a role in the etiology of the disease.
Is calcipotriol the same as Dovonex?
Calcipotriene (calcipotriol) is a synthetic drug derived from calcitriol otherwise known as vitamin D. It works by regulating the production and growth of skin cells. In the United States, this drug was first marketed under the trade name Dovonex and is used mainly for the treatment of psoriasis.
How does calcipotriol ointment work?
Calcipotriol works by slowing this overproduction of skin cells which eases the inflamed, scaly areas. It is similar to vitamin D, which is a vitamin essential for healthy skin. Sometimes calcipotriol is used in combination with a steroid medicine called betamethasone (as in a brand called Dovobet®).
How do you apply calcipotriol scalp solution?
Use this medication on the skin only. Comb the hair first to remove any scaly flakes. Apply the medication only to the affected areas of the scalp and gently rub in, usually twice daily or as directed by your doctor. Take care not to let any of the solution spread onto the forehead or any unaffected area.
Can you use Dovonex ointment on your scalp?
How to use Dovonex Solution. Use this medication on the skin only. Comb the hair first to remove any scaly flakes. Apply the medication only to the affected areas of the scalp and gently rub in, usually twice daily or as directed by your doctor.
Does Dovonex thin the skin?
Many people using this medication do not have serious side effects. Tell your doctor immediately if any of these unlikely but serious side effects occur: skin thinning/discoloration, stretch marks, “hair bumps” (folliculitis), unusual tiredness, mental/mood changes, unexplained constipation.
How long does it take for Dovonex to work?
Dovonex works by reducing the amount of cells your skin makes. This means your skin symptoms will reduce too. These diagrams explain how your skin may improve when you use this medicine. After about two weeks you may see a change in your skin.
Can I use calcipotriene cream on my scalp?
For plaque psoriasis: For topical dosage forms (cream, ointment, and scalp solution): Adults—Apply to the affected area of the skin or scalp once per day or two times per day as directed by your doctor. Children—Use and dose must be determined by your doctor.