What is the function of decorin?
The primary function of decorin involves regulation during the cell cycle. It has been involved in the regulation of autophagy, of endothelial cell and inhibits angiogenesis.
What is DCN gene?
Collapse Section. The DCN gene provides instructions for making a protein called decorin. This protein is a component of the extracellular matrix, which is the intricate lattice of proteins and other molecules that forms in the spaces between cells.
Where is Biglycan found?
bone
By the observation that biglycan-deficient mice display an osteoporosis-like phenotype, biglycan was discovered to be the first non-collageneous matrix component found in bone, being a regulator of bone formation and mass (Xu et al. 1998; Young et al. 2002).
What cells produce decorin?
3 Decorin contains a single glycosaminoglycan (GAG) chain composed of either dermatan or chondroitin sulfate, and 12 leucine-rich repeats comprising the protein core. Decorin is a stromal proteoglycan synthesized chiefly by fibroblasts, stressed vascular endothelial cells, and smooth muscle cells.
How does decorin bind to collagen?
In the chimeras, biglycan contributes sequences crucial for synthesis and export from the mammalian cells, and decorin provides potential collagen-binding properties. By using this approach we show that decorin binds to the collagen primarily via leucine-rich repeats 4-5 composed of some 40 amino acid residues.
What causes aggrecan?
Aggrecan is a multimodular molecule expressed by chondrocytes. Its core protein is composed of three globular domains (G1, G2, and G3) and a large extended region (CS) between G2 and G3 for glycosaminoglycan chain attachment. G1 comprises the amino terminus of the core protein.
Is hyaluronan a proteoglycan?
Hyaluronic acid is unique among the GAGs because it does not contain any sulfate and is not found covalently attached to proteins. It forms non-covalently linked complexes with proteoglycans in the ECM.
Is fibronectin a trimer?
Trimers of the fibronectin cell adhesion domain localize to actin filament bundles and undergo rearward translocation. J Cell Sci.
Does decorin protein core affect the global gene expression profile of xenografts?
DCN gene can inhibit the growth of nude mice xenograft, which is probably related with the decreased expressions of TGF-beta1 and MMP-9 protein and the inhibition of tumor angiogenesis. Decorin protein core affects the global gene expression profile of the tumor microenvironment in a triple-negative orthotopic breast carcinoma xenograft model.
What is the organization of the decorin gene?
The human decorin gene: intron-exon organization, discovery of two alternatively spliced exons in the 5′ untranslated region, and mapping of the gene to chromosome 12q23. (PMID: 8432526) Danielson KG … Iozzo RV (Genomics 1993) 2 3 4 21.
Is decorin an extracellular matrix?
Abstract Decorin is a member of the extracellular matrix small leucine-rich proteoglycans family that exists and functions in stromal and epithelial cells.
Is decorin a prognostic marker?
Decorin as a Biomarker for Prognosis There are very few studies on the prognostic significance of decorin expression levels. Because decorin expression is altered in several types of cancer, it is considered a possible prognostic marker in cancer patients.