What is the difference between Kcentra and Feiba?

What is the difference between Kcentra and Feiba?

FEIBA® is current formulary activated prothrombin complex concentrate (aPCC) product. KCentra® is current formulary prothrombin complex concentrate (PCC) product. Kcentra™ contains clotting factors II, VII, IX and X. It contains heparin and use should be avoided in patients where heparin is contraindicated.

How does Kcentra reverse warfarin?

The administration of Kcentra for urgent warfarin reversal increases plasma levels of the vitamin K–dependent coagulation Factors II, VII, IX, and X, as well as the antithrombotic Proteins C and S.

Is PCC the same as Kcentra?

Kcentra® is a four-factor prothrombin complex concentrate (PCC) approved by the FDA on April 29, 2013 for reversal of warfarin anticoagulation in patients experiencing serious bleeding events. It is the only four-factor PCC available in the U.S. at this time.

When is Kcentra used?

Kcentra (prothrombin complex) is a blood coagulation factor replacement product. Kcentra is used to quickly reverse the effects of a blood-thinning medicine (such as warfarin) during a major bleeding episode, or when there is a need for emergency surgery or invasive medical procedure.

What is Kcentra used for?

Kcentra, (Prothrombin Complex Concentrate (Human)), is indicated for the urgent reversal of acquired coagulation factor deficiency induced by Vitamin K antagonist (VKA, e.g., warfarin) therapy in adult patients with acute major bleeding.

What factors are in FEIBA?

FEIBA contains mainly non-activated factors II, IX, and X and mainly activated factor VII. It contains approximately equal unitages of factor VIII inhibitor bypassing activity and prothrombin complex factors.

Who manufactures FEIBA?

References: 1. FEIBA [Prescribing Information]. Lexington, MA: Baxalta US Inc.; 2019.

What is the INR of Kcentra?

In clinical trials, Kcentra decreased the INR to ≤1.3 within 30 minutes in most subjects. The relationship between this or other INR values and clinical hemostasis in patients has not been established [see Clinical Studies (14)].

How long does Kcentra affect INR?

Major bleeding despite INR: Administer vitamin K 5-10 mg IV with Kcentra INR will decrease over ~24- 48 hours (oral) and ~12-14 hours (IV); more frequent INR monitoring and additional vitamin K doses may be necessary.

Is Octaplex a PCC?

Octaplex is a modern, double virus safeguarded PCC with balanced content of vitamin K-dependent coagulation factors, which ensures fast onset of action and efficacious treatment, i.e. rapid correction of international normalized ratio (INR).

Can you give blood with Kcentra?

Use aseptic technique when administering Kcentra. a maximum rate of 8.4 mL/min (~210 units/min). No blood should enter the syringe, as there is a possibility of fibrin clot formation. Record the lot number of the product in the patient’s medical record when Kcentra is administered to the patient.

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