What is RPR Reflex to TP-PA?
RPR (Diagnosis) with Reflex to Titer and Confirmatory Testing – This is a non-treponemal screening test for syphilis. False positive results may occur due to systemic lupus erythematosus, leprosy, brucellosis, atypical pneumonia, typhus, yaws, pinta, or pregnancy.
What does a positive TPPA test mean?
pallidum antibody test (TPPA), suggests exposure to syphilis. Persons with a history of previous treatment will require no further treatment unless re-exposure is likely. In this instance, a repeat RPR in 2-4 weeks is recommended to evaluate for early infection.
What is TP-PA syphilis test?
The Serodia Treponema pallidum particle agglutination (TP-PA) test is a treponemal test for the serologic detection of antibodies to the various species and subspecies of pathogenic Treponema, the causative agents of syphilis, yaws, pinta, bejel, and endemic syphilis.
How is TPPA test done?
The TPHA blood test is a simple blood routine and does not require any specific preparations. A sample for the test is drawn by injecting the needle into a vein in your arm. Later it is sent to the lab for further analysis. In the lab, the TPHA test procedure is carried out by using a test card with three wells.
What causes a false-positive TPPA?
False-positive nontreponemal test results can be associated with various medical conditions unrelated to syphilis, including autoimmune disorders, older age, and injection drug use. Screening tests, such as the VDRL and RPR, are relatively simple to perform and provide rapid results.
When is RPR positive?
A positive RPR test should be followed by another type of test to diagnose syphilis. If you have been treated for syphilis in the past, an RPR test that shows a titer increase of fourfold means you likely have a new syphilis infection if you were not fully treated in the past.
How accurate is TPPA test?
There was a 97.3% agreement between TPPA and EIA. The EIA showed a sensitivity and specificity of 100% to detect active syphilis cases (Table 2).
What causes a false-positive TP-PA?
What causes a false positive TP-PA?
How long does a TPPA test take?
TP-PA: Treponema pallidium Particle Agglutination, Syphilis Serology: TP-PA Serum
| Test ID | LAB5172 |
|---|---|
| Availability | 1 run/week |
| NA | |
| Turnaround Time | 1-7 days |
| Reference Range | Non-reactive |
What can cause a positive RPR test?
Some conditions may cause a false-positive test, including:
- IV drug use.
- Lyme disease.
- Certain types of pneumonia.
- Malaria.
- Pregnancy.
- Systemic lupus erythematosus and some other autoimmune disorders.
- Tuberculosis (TB)
What is RPR test used for?
RPR (rapid plasma reagin) is a screening test for syphilis. It measures substances (proteins) called antibodies that are present in the blood of people who may have the disease. Blood is drawn from a vein (venipuncture), usually from the inside of the elbow or the back of the hand.