What is CD63 antibody?
CD63 (LAMP-3, lysosome-associated membrane protein-3), a glycoprotein of tetraspanin family, is present in late endosomes, lysosomes and secretory vesicles of various cell types. CD63 is also present in the plasma membrane, usually following cell activation.
What is H5C6?
Description: This H5C6 monoclonal antibody reacts with human CD63, a type III member of the tetraspanin family of transmembrane proteins. CD63 is expressed intracellularly on lysosomes, endosomes, and granules of resting platelets and basophils.
Where is CD81 found?
This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies. The tetraspanin family includes CD9, CD37, CD53, CD63, CD81 (this protein), CD82 and CD151. CD81 interacts directly with immunoglobulin superfamily member 8 (IGSF8, CD316) and CD36.
What is CD81 ligand?
CD81 belongs to the tetraspanin superfamily, whose members form specialized assemblies on the plasma membrane referred to as tetraspanin-enriched microdomains (TERMs). The specific ligand interactions within TERMs define cellular functions of tetraspanins (22).
What is CD81 a marker for?
CD81 is a tetraspanin cell surface protein that regulates CD19 expression in B lymphocytes and enables hepatitis C virus infection of human cells.
Is CD81 a receptor?
The large extracellular loop of CD81 binds the hepatitis E2 glycoprotein dimer. HCV-E2 and CD81 binding Kd is 1.8 nM. HCV-E2 engaged CD81 is only 30% internalized after 12hr, suggesting CD81 may be primarily an attachment receptor for HCV. It also appears to play a role in liver invasion by Plasmodium species.
What is a CD38 antibody?
CD38 monoclonal antibodies target the CD38 surface antigen of hematopoietic cells, which is important for cell function. Once CD38 monoclonal antibodies bind to the antigen it inhibits tumour growth by interrupting CD38 functions and causes cell death. CD38 monoclonal antibodies are used to treat multiple myeloma.
What does CD38 negative mean?
When the percentages of CD38+ cells were plotted for the entire patient population (data not shown), the patients could be segregated into 2 groups around the 20% level. Patients with 20% or more B cells expressing CD38 were considered positive, and those with less than 20% were considered negative.
What does h5c6 stand for?
Western Blot: CD63 Antibody (H5C6) [NBP2-42225] – THP1 whole cell protein was separated by SDS-PAGE on a 12% gel and transferred to PVDF membrane.
Where is CD63 found in a cell?
CD63 (LAMP-3, lysosome-associated membrane protein-3), a glycoprotein of tetraspanin family, is present in late endosomes, lysosomes and secretory vesicles of various cell types. CD63 is also present in the plasma membrane, usually following cell activation.
What is the role of CD63 in the diagnosis of cancer?
Expression of CD63 can be used for predicting the prognosis in earlier stages of carcinomas. CD63 is expressed on activated platelets, and is a lysosomal membrane glycoprotein that is translocated to plasma membrane after platelet activation.