What does ICAM-1 stand for?
The intercellular adhesion molecule (ICAM) 1 is an Ig-like cell adhesion molecule expressed by several cell types, including leukocytes and endothelial cells.
Is ICAM-1 a cytokine?
RANTES, or Regulated upon Activation Normal T-cell Expressed and Secreted, is a cytokine that is an inflammatory mediator chemotactic for a variety of inflammatory immune cells such as granulocytes and macrophages.
What does E-selectin stand for?
E-selectin, also known as CD62 antigen-like family member E (CD62E), endothelial-leukocyte adhesion molecule 1 (ELAM-1), or leukocyte-endothelial cell adhesion molecule 2 (LECAM2), is a selectin cell adhesion molecule expressed only on endothelial cells activated by cytokines.
How many types of selectins are there?
Selectins are cell surface lectins that have evolved to mediate the adhesion of leukocytes to endothelial cells and platelets under flow. Three selectins have been identified: L-selectin (leukocyte selectin), P-selectin (platelet selectin), and E-selectin (endothelial selectin).
Do integrins bind to ICAMs?
The leukocyte β2 integrins are heterodimeric molecules on the surface of neutrophils, monocytes and lymphocytes that bind to intercellular adhesion molecules (ICAMs) on the endothelial surface in order to attach and exit the circulation.
Are selectins lectins?
All selectins are single-chain transmembrane glycoproteins that share similar properties to C-type lectins due to a related amino terminus and calcium-dependent binding. Selectins bind to sugar moieties and so are considered to be a type of lectin, cell adhesion proteins that bind sugar polymers.
Do selectins bind to integrins?
The selectins are able to bind to the leukocyte integrins and activate them, probably by the induction of a conformational change. The activated integrins subsequently bind to the ICAM-molecules on the endothelial cell and firm attachment occurs.
What is CAM in immunology?
Cell adhesion molecules (CAMs) are a subset of cell surface proteins that are involved in the binding of cells with other cells or with the extracellular matrix (ECM), in a process called cell adhesion. In essence, CAMs help cells stick to each other and to their surroundings.