What causes neuronal migration disorder?
What causes a neuronal migration disorder? Doctors think that neuronal migration disorders are genetic in that a faulty gene stops the neural circuits forming properly. Some neuronal migration disorders are passed on from parent to child, but most develop as a sporadic genetic fault that just happens.
Can neuronal migration be cured?
There is no treatment for neuronal migration defect, but treatment is focused on the symptoms, which can include seizure. While the seizures associated with this condition are difficult to control with medication, special diet and surgery can help control them.
What is cell migration in the brain?
Neuronal migration is a fundamental process in central nervous system (CNS) development. The assembly of functioning neuronal circuits relies on neuronal migration occurring in the appropriate spatio-temporal pattern. A defect in the neuronal migration may result in a neurological disorder.
What is Pachygyria syndrome?
Pachygyria is a developmental condition due to abnormal migration of nerve cells (neurons) in the developing brain and nervous system.[1568] With pachygyria, there are few gyri (the ridges between the wrinkles in the brain), and they are usually broad and flat.
Does neuronal migration occur in adults?
As these neurons migrate for long distances through adult brain tissue, they are supported by various guidance cues and structures that act as scaffolds. Some of these mechanisms are unique to neuroblast migration in the adult brain, and are not involved in migration in the developing brain.
What is lissencephaly disease?
Lissencephaly, which literally means “smooth brain,” is a rare, gene-linked brain malformation characterized by the absence of normal convolutions (folds) in the cerebral cortex and an abnormally small head (microcephaly). In the usual condition of lissencephaly, children usually have a normal sized head at birth.
What is Miller dieker syndrome?
Miller-Dieker syndrome is a condition characterized by a pattern of abnormal brain development known as lissencephaly. Normally the exterior of the brain (cerebral cortex ) is multi-layered with folds and grooves. People with lissencephaly have an abnormally smooth brain with fewer folds and grooves.
What is neuronal connectivity?
1. Connections between neurons where neuron sends information via neurotransmitter. Learn more in: Recent Advances and Neural Connectivity in Autism.