What bacteria does daptomycin cover?

What bacteria does daptomycin cover?

Daptomycin is a cyclic lipopeptide antibiotic derived from the organism Streptomyces roseosporus. Daptomycin is used to treat various bacterial infections caused by Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE).

What class of antibiotic is daptomycin?

Daptomycin injection is in a class of medications called cyclic lipopeptide antibiotics. It works by killing bacteria.

Is daptomycin a broad spectrum antibiotic?

Purpose: : Daptomycin is a broad-spectrum antibiotic for Gram-positive bacteria, including those with vancomycin resistance. The rapid and complete bactericidal activity, long half-life, minimal resistance, and lack of cell-wall lysis with bacterial death compare favorably to vancomycin.

What bugs does daptomycin cover?

Daptomycin exhibits rapid bactericidal activity against Enterococcus spp., including vancomycin-susceptible and vancomycin-resistant strains of E. faecium and E. faecalis. In vitro activity of daptomycin has also been documented for Cornybacterium spp., Bacillus spp., and Listeria monocytogenes.

What labs do you monitor with daptomycin?

Because daptomycin can cause reversible skeletal myopathy, patients should be monitored for muscle pain or weakness, and serum creatine kinase levels should be checked weekly.

Does daptomycin cover E coli?

The target of daptomycin is absent from Escherichia coli and other gram-negative pathogens. Antimicrob Agents Chemother.

Is daptomycin the same as vancomycin?

Daptomycin, a lipopeptide antibiotic, is approved by the US Food and Drug Administration for the treatment of S. aureus bacteremia and is considered a reasonable alternative to vancomycin. The efficacy of daptomycin has been demonstrated in an open-label randomized clinical trial by Fowler et al.

Does daptomycin cover Streptococcus?

Daptomycin has activity against Streptococcus spp. including penicillin-susceptible and penicillin-resistant strains of S. pneumoniae, beta-hemolytic streptococci, and Viridans streptococci.

Is daptomycin used for MRSA?

Considering its safety profile and rapid bactericidal action, and also ease of administration with once daily dose, daptomycin may be useful for the treatment of severe infection caused by MRSA.

What should be monitored while on daptomycin?

Patients receiving daptomycin should be monitored for the development of muscle pain or weakness. Consideration should be given to temporarily suspending agents associated with rhabdomyolysis.

What is daptomycin used to treat Gram positive bacteria?

ReviewDaptomycin: a lipopeptide antibiotic for the treatment of serious Gram-positive infections. [J Antimicrob Chemother. 2005] ReviewDaptomycin: a lipopeptide antibiotic for the treatment of serious Gram-positive infections. Steenbergen JN, Alder J, Thorne GM, Tally FP.

Can daptomycin be used to treat S aureus?

In 2006, daptomycin was approved as a once-daily therapy (6 mg/kg) for the treatment of S. aureusbloodstream infections (bacteremia), including right-sided endocarditis caused by MSSA and MRSA [47]. The use of daptomycin has been investigated in bone and joint infections.

What is the age limit for Daptomycin?

Daptomycin is not recommended in pediatric patients younger than one year of age due to its likely effects on the muscular, neuromuscular, and/or nervous systems. [5] Mechanism of Action Daptomycin is a cyclic lipopeptide antibiotic that exerts its bactericidal effect by disrupting multiple aspects of bacterial cell membrane function.

What are the risks of daptomycin treatment?

Like other antibiotics, prolonged or inappropriate treatment with daptomycin can lead to bacterial resistance. Therefore, providers need to be aware of increased antibiotic resistance patterns and practice appropriate antimicrobial stewardship.