What are FAB subtypes?
The FAB classification recognizes eight subtypes of AML: M0 minimal myeloid differentiation (3%), M1 poorly differentiated myeloblasts (15–20%), M2 myeloblastic with differentiation (25–30%), M3 promyelocytic (5–10%), M4 myelo-monoblastic (20%), M5 monoblastic (2–9%), M6 erythroblastic (3–5%), and M7 megakaryoblastic ( …
How is AML graded?
AML subtypes and staging Using a system known as French-American-British (FAB) classification, AML is classified in eight subtypes, M0 through M7, based on: The number of healthy blood cells. The size and number of leukemia cells. The changes that appear in the chromosomes of the leukemia cells.
WHO classification of AML is based on?
The World Health Organization (WHO) classification is the main system used to classify AML into subtypes. It includes prognostic (predictive) factors, such as chromosomal abnormalities and genetic mutations, which are known to affect the future outcome of the cancer.
What is AML M2?
Acute myeloblastic leukemia with maturation (M2) is a subtype of acute myeloid leukemia (AML). Acute myeloid leukemia (AML) is a type of cancer affecting blood cells that eventually develop into non-lymphocyte white blood cells.
WHO classification AML 2018?
The newer WHO classification is as follows : AML with recurrent genetic abnormalities: AML with t(8;21)(q22;q22), (AML1/ETO); AML with abnormal bone marrow eosinophils and inv(16)(p13q22) or t(16;16)(p13)(q22), (CBFB/MYH11); APL with PML/RARa; AML with t(9;11)(p21. 3;q23. 3), (MLLT3-KMT2A); AML with t(6;9)(p23;q34.
What does INV 16 mean?
The inv(16) is one of the most frequent chromosomal translocations associated with acute myeloid leukemia (AML). The inv(16) fusion protein acts by dominantly interfering with AML-1/core binding factor β-dependent transcriptional regulation.
What is myeloid malignancy?
Myeloid malignancies are clonal diseases of hematopoietic stem or progenitor. cells.4 These malignancies can be present in the bone marrow and peripheral blood. They result from genetic and epigenetic alterations that perturb key processes such as. self-renewal, proliferation and impaired differentiation.5,6.