Is ceruloplasmin a copper chaperone?

Is ceruloplasmin a copper chaperone?

Ceruloplasmin (or caeruloplasmin) is a ferroxidase enzyme that in humans is encoded by the CP gene. Ceruloplasmin is the major copper-carrying protein in the blood, and in addition plays a role in iron metabolism. It was first described in 1948.

Is ceruloplasmin a copper transporter?

Ceruloplasmin mobilizes iron into the plasma from iron storage cells in the liver. An equally important duty is that ceruloplasmin, after its rapid biosynthesis in the liver, serves as a major copper transport vehicle, comparable to transferrin.

Is ceruloplasmin a blue copper protein?

Ceruloplasmin is a blue copper protein found in the alpha 2-globulin fraction of vertebrate plasma. It is a single-chain glycoprotein of molecular weight 132 000. It contains six copper atoms per molecule, comprising three or possibly four different types of copper.

What is the biological significance of ceruloplasmin?

Ceruloplasmin mobilizes iron into the plasma from iron storage cells in the liver. An additional role of Cp may be as a contributor to the regulation of the balance of biogenic amines through its oxidase action on the epinephrine and the hydroxyindole series.

What is the normal range for ceruloplasmin?

Normal Results The normal range for adults is 14 to 40 mg/dL (0.93 to 2.65 µmol/L). Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or may test different samples. Talk to your provider about the meaning of your specific test results.

What does low ceruloplasmin indicate?

A lower than normal level of ceruloplasmin may mean your body is not able to use or eliminate copper properly. It can be a sign of: Wilson disease. Menkes syndrome. Liver disease.

What is considered high ceruloplasmin?

The normal range for a ceruloplasmin serum test is 20 to 35 milligrams per deciliter (mg/dL). If you have Wilson disease, your ceruloplasmin level will probably be below 10 mg/dL. Low ceruloplasmin might also mean Menkes disease. This is a genetic disorder that makes it hard for your body to absorb copper.

What if your ceruloplasmin is high?

If your ceruloplasmin levels were higher than normal, it may be a sign of: A serious infection. Heart disease. Rheumatoid arthritis.