WHO histological classification of ovarian cancer?
The histological classification of ovarian tumors by the World Health Organization (WHO) is based on histogenetic principles, and this classification categorizes ovarian tumors with regard to their derivation from coelomic surface epithelial cells, germ cells, and mesenchyme (the stroma and the sex cord).
What are the subtypes of ovarian cancer?
Although it is usually regarded as a single disease, there are actually several distinct subtypes of ovarian carcinoma. These are classified according to their microscopic appearance as high-grade serous, low-grade serous, clear cell, endometrioid, and mucinous ovarian carcinomas.
What are the subtypes of epithelial ovarian cancer?
Primary epithelial ovarian carcinoma is sub-classified into serous, mucinous, endometrioid and clear cell subtypes. Neoadjuvant chemotherapy has become an alternative treatment option past several years, as serous carcinoma, the most common subtype, is known as chemotherapy-sensitive tumor.
How many types of ovary are there?
Your ovaries have three main types of cells, and a tumor can develop in any of them. The three types are: Epithelial cells, which cover the surface of your ovary. Germ cells, which make your eggs (ova)
WHO classification ovarian cysts?
An ovarian cyst is a sac filled with liquid or semiliquid material that arises in an ovary. Such cysts can be broadly classified as either functional or neoplastic. Neoplastic ovarian cysts can be either benign or malignant. This slide shows a large benign serous cystadenoma of an ovary at the time of surgery.
Is ovarian cancer benign or malignant?
Most ovarian germ cell tumors are benign, but some are cancerous and may be life threatening. Less than 2% of ovarian cancers are germ cell tumors. Overall, they have a good outlook, with more than 9 out of 10 patients surviving at least 5 years after diagnosis.
Can you have ovarian cancer in both ovaries?
Stage IB has cancer in both ovaries or fallopian tubes. In stage IC, cancer is in both ovaries or fallopian tubes and it’s found outside of the ovary (on the outside of the organ itself or in the space around the ovary, called the peritoneal cavity). Stage II: Stage II is also divided into a few additional stages.
How many types of ovarian cancer are there?
There are three types of ovarian cancers: epithelial ovarian carcinomas, germ cell tumors, and stromal cell tumors. Each has different characteristics and traits: About 85% to 90% of these cancers start in the cells that cover the outer surface of the ovary.
What is non epithelial ovarian cancer?
Nonepithelial ovarian cancers (NEOCs) are rare forms of ovarian cancer, including malignant ovarian germ cell tumours (MOGCTs), sex cord-stromal tumours (SCSTs) and ovarian sarcoma.
What is ovarian malignancy?
Ovarian cancer is a type of cancer that begins in the ovaries. The ovaries — each about the size of an almond — produce eggs (ova) as well as the hormones estrogen and progesterone. Ovarian cancer is a growth of cells that forms in the ovaries. The cells multiply quickly and can invade and destroy healthy body tissue.
Are there histologic subtypes of ovarian carcinoma?
Histologic subtypes of ovarian carcinoma: an overview Reproducible subclassification of ovarian carcinomas is biologically and increasingly therapeutically important. The traditional morphologic approach that ignores genotype and immunophenotype is subjective and therefore suboptimal.
Does histology play a role in the global distribution of ovarian cancer?
Ovarian cancers comprise several histologically distinct tumour groups with widely different prognosis. We aimed to describe the worldwide distribution of ovarian cancer histology and to understand what role this may play in international variation in survival. Methods
What do we know about ovarian carcinoma morphology?
This review covers the prevalence, morphology, immunophenotype and, … Reproducible subclassification of ovarian carcinomas is biologically and increasingly therapeutically important. The traditional morphologic approach that ignores genotype and immunophenotype is subjective and therefore suboptimal.
What is the pathophysiology of ovarian cancer?
The pathogenesis of ovarian cancer is not fully understood. Recent evidence, particularly from prophylactic oophorectomies in women at a high risk of ovarian cancer because of BRCA gene mutations, suggests that the most common subtype, high-grade serous carcinoma, originates either in the fallopian tube or on the surface of the ovary.