Which enzyme is secreted by the juxtaglomerular cells of the kidney?
Renin
HYPERTENSION | Physiology Renin is an enzyme secreted by the juxtaglomerular cells of the kidney.
What hormone do macula densa cells secrete?
Renin Release
Macula-Densa Control of Renin Release The macula densa participates in the regulation of renin release from juxtaglomerular granular cells. Renin secretion depends on NaCl delivery to and reabsorption by the macula-densa cells at the end of the TAL.
Do macula densa cells secrete renin?
The macula densa, in response to the change in the Na concentration in the distal tubules, signals the juxtaglomerular cells to release renin. Renin is stored in granules and the secretion is stimulated by the β-adrenergic response and cAMP augmentation.
What do macula densa cells release?
Macula densa cells in the distal nephron, according to the classic paradigm, are salt sensors that generate paracrine chemical signals in the juxtaglomerular apparatus to control vital kidney functions, including renal blood flow, glomerular filtration, and renin release.
What do macula densa cells do?
Macula densa (MD) cells are chief cells within the kidney, playing key sensory and regulatory functions in the maintenance of body fluid, electrolyte homeostasis, and blood pressure.
What do juxtaglomerular cells produce?
The juxtaglomerular cells secrete renin, and as specialised smooth muscle cells surrounding the afferent arteriole also have the capacity to affect the perfusion of the glomerulus.
What is the function of the macula densa cells of the Juxtaglomerular complex?
What do macula densa cells detect?
Macula densa cells are renal sensor elements that detect changes in distal tubular fluid composition and transmit signals to the glomerular vascular elements. This tubuloglomerular feedback mechanism plays an important role in regulating glomerular filtration rate and blood flow.
What is the function of the macula densa and juxtaglomerular cells?
In response to elevated sodium, the macula densa cells trigger contraction of the afferent arteriole, reducing flow of blood to the glomerulus and the glomerular filtration rate. The juxtaglomerular cells, derived from smooth muscle cells, of the afferent arteriole secrete renin when blood pressure in the arteriole falls.
Where is the macula densa located?
As the distal tubule ascends into the cortex, there is a specialized group of cells called the macula densa that lies in close proximity to the juxtaglomerular region of the glomerulus (Figure 19).
How is renin secreted from the macula densa?
Macula-Densa Control of Renin Release The macula densa participates in the regulation of renin release from juxtaglomerular granular cells. Renin secretion depends on NaCl delivery to and reabsorption by the macula-densa cells at the end of the TAL.
How do juxtaglomerular cells secrete renin?
The juxtaglomerular cells, derived from smooth muscle cells, of the afferent arteriole secrete renin when blood pressure in the arteriole falls. Renin increases blood pressure via the renin-angiotensin-aldosterone system. Lacis cells, also called extraglomerular mesangial cells, are flat and elongated cells located near the macula densa.