What medications cause dystonic reactions?

Neuroleptics (antipsychotics), antiemetics, and antidepressants are the most common causes of drug-induced dystonic reactions. Acute dystonic reactions have been described with every antipsychotic. Alcohol and cocaine use increase risk.

How do you reverse a dystonic reaction?

Most people have diphenhydramine (Benadryl) at home that they should take immediately, before heading to the ED. In the emergency room or clinic, the parenteral administration of an anticholinergic (1 to 2 mg benztropine or 25-50 mg diphenhydramine) usually leads to rapid and complete resolution of the ADR.

Which drug is given for metoclopramide induced dystonic reaction?

The most rapid treatment of an acute dystonic reaction caused by metoclopramide is the intravenous or intramuscular administration of anticholinergics.

Which medications can be given to treat dystonia who are the medications administered?

Treatment

Carbidopa-levodopa (Duopa, Rytary, others). This medication can increase levels of the neurotransmitter dopamine.
Trihexyphenidyl and benztropine (Cogentin).
Tetrabenazine (Xenazine) and deutetrabenazine (Austedo).
Diazepam (Valium), clonazepam (Klonopin) and baclofen (Lioresal, Gablofen).

What medication causes dyskinesia?

Medicines that most commonly cause this disorder are older antipsychotics, including:

Chlorpromazine.
Fluphenazine.
Haloperidol.
Perphenazine.
Prochlorperazine.
Thioridazine.
Trifluoperazine.

Can medication help dystonia?

Diazepam (Valium), clonazepam (Klonopin) and baclofen (Lioresal, Gablofen). These medications reduce neurotransmission and might help some forms of dystonia.

Does Benadryl help dystonia?

Main Outcome Measure: Dystonia evaluation. Results: Diphenhydramine therapy was associated with minimal side effects, and it was most effective in treating patients with dystonia who experienced lightning jerks.

Is Benadryl used for dystonia?

How does benztropine treat dystonia?

Benztropine is used in acute dystonic reactions, it blocks striatal cholinergic receptors, thus helping to balance the cholinergic and dopaminergic activity.

Do muscle relaxers help with dystonia?

Baclofen is a muscle relaxer that is commonly used to treat select cases of dystonia, for example dystonia following traumatic injury to the central nervous system. Carbidopa and levodopa can increase levels of the neurotransmitter dopamine. A reduced level of dopamine is one of the possible causes of dystonia.

Can trihexyphenidyl make dystonia worse?

The BADS score was 2.67 points higher (95% confidence interval (CI) -2.55 to 7.90; low-quality evidence), that is, worse dystonia, in the treated group. Trihexyphenidyl may be associated with an increased risk of adverse effects (risk ratio 2.54, 95% CI 1.38 to 4.67; low-quality evidence).

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