What is the role of fibroblast growth factor 23 on kidney?
Fibroblast growth factor-23 (FGF23) is a bone-derived hormone suppressing phosphate reabsorption and vitamin D hormone synthesis in the kidney.
How is fibroblast growth factor 23 important to bone health?
The FGF23 gene provides instructions for making a protein called fibroblast growth factor 23, which is produced in bone cells. This protein is necessary in regulating the phosphate levels within the body (phosphate homeostasis).
When is FGF23 secreted?
FGF23 is secreted by osteocytes in response to increased calcitriol. FGF23 acts on the kidneys, where it decreases the expression of NPT2, a sodium-phosphate cotransporter in the proximal tubule. Thus, FGF23 decreases the reabsorption of calcium and increases excretion of phosphate.
What stimulates FGF23?
FGF-23 is a 251–amino acid hormone predominantly produced from bone cells (osteocytes and osteoblasts) during active bone remodeling, but its mRNA is also found in the heart, liver, thyroid/parathyroid, intestine, and skeletal muscle. FGF-23 production in the osteocyte is stimulated by PTH67 and calcitriol.
Does fibroblast growth factor 23 increase bone growth?
Recent studies have revealed that the levels of FGF23 increase significantly at the very early stages of chronic kidney disease (CKD) and may play a critical role in mineral ion disorders and bone metabolism in these patients.
What causes fibroblast growth factor?
Fibroblast growth factors (FGF) are a family of cell signalling proteins produced by macrophages; they are involved in a wide variety of processes, most notably as crucial elements for normal development in animal cells. Any irregularities in their function lead to a range of developmental defects.
How many fibroblast growth factors are there?
four
The mammalian FGF family is composed of 18 ligands that elicit their actions through four highly conserved transmembrane tyrosine kinase receptors (FGFR1, FGFR2, FGFR3, and FGFR4) [12]. Four FGFRs have been identified in humans and mice and encode receptor tyrosine kinases (ca.
What is an example of a growth factor?
Examples of protein growth factors are vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), and platelet-derived growth factor (PDGF). Growth factor specificity to particular cell types is achievable by the expression of highly specific cell surface receptors.
Where is hepatocyte growth factor found?
Various cells produce HGF, including polymorphonucleocytes, fibroblasts, epithelial cells, endothelial cells, Kupffer cells and fat-storing cells in the liver. HGF protein and high levels of mRNA have also been found in intestine, brain, thyroid, thymus and placenta.
Is 12-hour fasting required for FGF-23 studies?
A morning 12-hour fasting sample is recommended but not required. Fibroblast growth factor 23 (FGF-23), a member of the fibroblast growth factor (FGF) family of proteins, is a phosphaturic hormone predominantly produced by bone osteocytes. 1-6 Plasma FGF-23 exerts its actions by binding to the FGF receptors on cell membranes.
What is FGF 23 made of?
Fibroblast growth factor 23 (FGF-23), a member of the fibroblast growth factor (FGF) family of proteins, is a phosphaturic hormone predominantly produced by bone osteocytes. 1-6 Plasma FGF-23 exerts its actions by binding to the FGF receptors on cell membranes.
How does FGF-23 inhibit phosphate reabsorption?
Effective FGF-23 binding to these cell surface receptors requires that the cell membrane also contain the transmembrane protein, Klotho. 1,7-10 FGF-23 inhibits phosphate reabsorption by suppressing Na/Pi cotransporter activity in the proximal convoluted tubule of the kidney.
What does FGF-23 stand for?
Human FGF-23 (C-Term) ELISA Kit, 2nd Generation Enzyme-Linked ImmunoSorbent Assay (ELISA) for the Determination of Human Fibroblast Growth Factor 23 Levels in Plasma or Cell Culture Media. [package insert] Immutopics Inc; January 2009. 90-6100. © 2021 Laboratory Corporation of America® Holdings and Lexi-Comp Inc.