What is the action of atropine?
Atropine reduces secretions in the mouth and respiratory passages, relieves the constriction and spasm of the respiratory passages, and may reduce the paralysis of respiration that results from toxic nerve agents which increase anticholinesterase activity in the central nervous system.
What is the action of atropine on pulse and pupils?
Atropine causes the muscles in your eye to become relaxed. This widens (dilates) your pupil so that it will not respond to light.
What does atropine do in emergency?
It is used in emergency situations when the heart beats too slowly, as an antidote to for example organophosphate insecticide or nerve gas poisoning and in mushroom poisoning. It can be used as part of the premedication before general anaesthesia.
What is the onset of action of atropine?
Pharmacodynamics. The onset of action after administration of atropine sulfate ophthalmic solution, USP 1%, is usually within 40 minutes with maximal effect being reached in about 2 hours. The effect can last for up to 2 weeks in a normal eye.
What receptors does atropine act?
Atropine acts as a competitive, reversible antagonist of muscarinic receptors: an anticholinergic drug. This activity outlines the indications, mechanism of action, safe administration, adverse effects, contraindications, toxicology, and monitoring of atropine.
Why is atropine used for bradycardia?
Abstract. The use of atropine in cardiovascular disorders is mainly in the management of patients with bradycardia. Atropine increases the heart rate and improves the atrioventricular conduction by blocking the parasympathetic influences on the heart.
How does atropine cause dilation of the pupil?
This medicine works by blocking the chemical acetylcholine, which relaxes the ciliary muscle of the eye and causes the pupil to dilate.
How does atropine work on the heart?
Atropine increases the heart rate and improves the atrioventricular conduction by blocking the parasympathetic influences on the heart.
When do we give atropine?
Atropine is usually given as soon as possible after the onset of poisoning symptoms. You may be watched for up to 72 hours to make sure the medicine has been effective and you no longer have any effects of the poison.
When do you give atropine IV?
Intravenous (IV) atropine indications include patients with hypersalivation, bronchial secretions, or bradycardia. Large doses and repeat doses may be required. Ingestions especially require higher doses (up to 20 mg). Titrate to effect by monitoring the patient’s ability to clear excess secretions.
When do you give atropine?
Atropine is useful for treating symptomatic sinus bradycardia and may be beneficial for any type of AV block at the nodal level. The recommended atropine dose for bradycardia is 0.5 mg IV every 3 to 5 minutes to a maximum total dose of 3 mg.
How does atropine work for bradycardia?
The use of atropine in cardiovascular disorders is mainly in the management of patients with bradycardia. Atropine increases the heart rate and improves the atrioventricular conduction by blocking the parasympathetic influences on the heart.