What is multivalent binding?

What is multivalent binding?

(1) Multivalent binding is defined as when multiple ligands on one species bind to multiple receptors on another species simultaneously. This can create a much stronger binding interaction than the sum of the corresponding monovalent single receptor/ligand interactions.

What is a multivalent structure?

A multivalent ligand is composed of a scaffold or backbone to which a particular number (valency) of identical or non-identical epitopes are attached.

What is a multivalent scaffold?

It refers to multiple noncovalent interactions between a multiple ligand-containing scaffold and a target with multiple recognition sites, a common case in biological processes such as immunologic response, cell membrane adherence, signal transduction, and several enzymatic systems.

What is multivalent protein?

To compensate for their low affinity, most protein–carbohydrate interactions are multivalent. Multivalent interactions occur when multiple binding groups (e.g., carbohydrates) on one cell bind to multiple copies of a receptor (e.g., a protein) on another cell.

What are multivalent ligands?

A multivalent ligand comprises of multiple copies of ligands conjugated to scaffolds, allowing the simultaneous binding of multivalent ligands to multiple binding sites or receptors.

What does multivalent antigen mean?

having a valence of three or higher. Immunology. containing several kinds of antibody. pertaining to an antibody that contains many antigen-binding sites. pertaining to an antibody that has many determinants.

What does it mean to be multivalent?

Definition of multivalence : the quality or state of having many values, meanings, or appeals.

What does the word multivalent mean?

Definition of multivalent 1 : polyvalent. 2 : represented more than twice in the somatic chromosome number multivalent chromosomes. 3 : having many values, meanings, or appeals.