What is B lymphocytosis?
A condition in which a higher-than-normal number of identical B cells are found in the blood. People with monoclonal B-cell lymphocytosis may develop other B-cell diseases, such as chronic lymphocytic leukemia (CLL). Also called MBL.
What does it mean when B cells are polyclonal?
Polyclonal B cell response is a natural mode of immune response exhibited by the adaptive immune system of mammals. It ensures that a single antigen is recognized and attacked through its overlapping parts, called epitopes, by multiple clones of B cell.
What are the symptoms of monoclonal B-cell lymphocytosis?
| Monoclonal B-cell lymphocytosis | |
|---|---|
| Symptoms | None |
| Complications | May progress to chronic lymphocytic leukemia or certain lymphoma types; increased risk of developing non-hematologic cancers, serious infections, and kidney disease |
| Duration | chronic |
| Types | CLL/SLL, atypical CLL/SLL, non-CLL/SLL, and MBL-MZ |
What does abnormal B-cell population mean?
When you have B-cell lymphoma, your body makes too many abnormal B cells. These cells can’t fight infections well. They can also spread to other parts of your body. There are two types of lymphoma: Hodgkin’s lymphoma and non-Hodgkin’s lymphoma.
What causes elevated B cells?
An increased B cell count may be due to: Chronic lymphocytic leukemia. DiGeorge syndrome. Multiple myeloma.
What causes polyclonal B cell activation?
It is well documented that some microbial molecules and microorganisms can directly induce the proliferation and differentiation of antibody-secreting cells from different B cells, regardless of their antigen specificity. This phenomenon is known as polyclonal B cell activation.
Are polyclonal B cells normal?
Persistent polyclonal B-cell lymphocytosis (PPBL) is a rare benign disease with chronic lymphocytosis of polyclonal origin, first described in 1982, which occurs more frequently in middle-aged female smokers. These are mostly mild lymphocytosis and are mostly symptom-free or show unspecific symptoms such as fatigue.
How often does MBL turn into CLL?
A number of biological and genetic characteristics distinguish low-count from high-count MBL. Whereas low-count MBL rarely progresses to CLL, high-count MBL progresses to CLL requiring therapy at a rate of 1% to 2% per year.
Is there a cure for monoclonal B-cell lymphocytosis?
Monoclonal B-cell lymphocytosis (MBL) MBL is not cancer. MBL doesn’t require treatment, but you will need regular blood tests to monitor your lymphocyte count. A small number of people with MBL develop CLL, which may eventually require treatment.