What drugs are T-type calcium channel blockers?
Table 1
| Drug | Pathways Inhibited | MW (g/mole) |
|---|---|---|
| Amlodipine | T-Type (CaV3.2>CaV3.1 or CaV3.3) and L-Type; Na; K | 408.88 |
| Aranidipine*J | T-Type and L-Type | 388.37 |
| Azelnidipine*CJ | T-Type and L-Type | 582.65 |
| Barnidipine*SJO | T-Type and L-Type | 528 |
What do T-type calcium channels do?
T-type calcium channels function to control the pace-making activity of the SA Node within the heart and relay rapid action potentials within the thalamus. These channels allow for continuous rhythmic bursts that control the SA Node of the heart.
Are calcium channel blockers used to treat epilepsy?
Currently, only calcium channel blockers are used, which are rarely clinically used as standalone therapy for epilepsy.
Does valproate inhibit calcium channels?
Valproate also has effects on L-type calcium channels, sodium channels and voltage gated potassium channels [88] as well as attenuating NMDA-mediated excitation [89,90].
Is Amlodipine a T-type calcium channel blocker?
Amlodipine, an L-type calcium channel blocker, protects against chlorpromazine-induced neurobehavioural deficits in mice. Fundam Clin Pharmacol.
Why is calcium important in epilepsy?
Can low levels of minerals in the body affect seizure activity? Minerals are essential nutrients. Low levels of the minerals sodium, calcium, and magnesium can alter the electrical activity of brain cells and cause seizures.
Can amlodipine cause seizures?
Dial 911 or report to an emergency department if wheezing, facial swelling, chest tightness, cough, or seizures occur suddenly. Do not stop taking amlodipine suddenly. Although no “rebound” effect has been reported, it is better to slowly decrease the dosage over a period of time.
Is Depakote a CNS depressant?
Since DEPAKOTE products may produce CNS depression, especially when combined with another CNS depressant (eg, alcohol), patients should be advised not to engage in hazardous activities, such as driving an automobile or operating dangerous machinery, until it is known that they do not become drowsy from the drug.