What drugs are EGFR inhibitors?

What drugs are EGFR inhibitors?

Currently, there are five FDA-approved drugs that inhibit EGFR: 3 TKIs (erlotinib [Tarceva, Genentech, South San Francisco, CA/OSI Pharmaceuticals, Melville, NY], gefitinib [Iressa, AstraZeneca, Wilmington, DE], and lapatinib [Tykerb, GlaxoSmithKline, Middlesex, England]) and two mAbs (cetuximab [Erbitux, ImClone …

What is EGFR tyrosine kinase inhibitors?

A substance that blocks the activity of a protein called epidermal growth factor receptor (EGFR). EGFR is found on the surface of some normal cells and is involved in cell growth.

How effective are EGFR inhibitors?

Our main finding was that the addition of EGFR MAb drugs to standard treatment in people whose tumours were KRAS wild type reduces the risk of disease progression by 30%. The risk of death is reduced by 12% (i.e. patients live longer overall), and the chance of tumour shrinkage is increased from 31% to 46%.

Are EGFR inhibitors chemotherapy?

Single-agent epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) is a standard first-line therapy for patients with activating-EGFR mutation such as base-pair deletion in exon 19 or point mutation at exon 21. At the same time, this class of drugs may be combined with chemotherapy.

How do you block GFR?

Two main classes of inhibitors target EGFR: monoclonal antibody (mAb)-based drugs and small molecule tyrosine kinase inhibitors (TKIs). The main action of mAbs is to bind to the extracellular domain (ECD) of EGFR, which blocks ligand-receptor binding and consequently results in the abrogation of EGFR dimerization.

How are receptor tyrosine kinases inhibited?

A tyrosine kinase inhibitor (TKI) is a pharmaceutical drug that inhibits tyrosine kinases. Tyrosine kinases are enzymes responsible for the activation of many proteins by signal transduction cascades. The proteins are activated by adding a phosphate group to the protein (phosphorylation), a step that TKIs inhibit.

What happens if EGFR is mutated?

EGFR (epidermal growth factor receptor) is a protein on cells that helps them grow. A mutation in the gene for EGFR can make it grow too much, which can cause cancer.

What eGFR means in blood test?

The estimated glomerular filtration rate (eGFR) is a test that measures your level of kidney function and determines your stage of kidney disease. Your healthcare team can calculate it from the results of your blood creatinine test, your age, body size, and gender.