What does chloramphenicol do to humans?
Chloramphenicol is used in the treatment of infections caused by bacteria. It works by killing bacteria or preventing their growth.
What are the long term side effects of taking dapsone?
Rarely, prolonged use of dapsone over months or years at a high dose can lead to impaired function of nerves in the limbs, causing weakness of muscles in the hands and feet.
Why does chloramphenicol cause bone marrow toxicity?
The common, dose-dependent, reversible bone marrow suppression from chloramphenicol is a consequence of mitochondrial injury. The greater erythroid susceptibility to chloramphenicol appears to be a function of the endogenous mitochondrial amino acid pools.
Why is chloramphenicol hazardous?
Material may be irritating to the mucous membranes and upper respiratory tract. May be harmful by inhalation, ingestion, or skin absorption. May cause eye, skin, or respiratory system irritation. Suspected of causing cancer.
Can dapsone cause heart problems?
Dapsone has the potential to cause ventricular arrhythmias in patients with ischaemic cardiomyopathy. When a patient’s care is at the end stages of recognized treatment to consider withdrawal of medication as an appropriate action.
Does dapsone increase heart rate?
Many people using this medication do not have serious side effects. Tell your doctor immediately if any of these unlikely but serious side effects occur: unusually fast heartbeat, unusually fast breathing, bluish lips/skin, chest pain, mental/mood changes, muscle weakness, difficulty urinating.
Is Hansen’s disease curable?
It can affect the nerves, skin, eyes, and lining of the nose (nasal mucosa). With early diagnosis and treatment, the disease can be cured. People with Hansen’s disease can continue to work and lead an active life during and after treatment.
Does chloramphenicol cause leukemia?
Chloramphenicol is reasonably anticipated to be a human carcinogen, based on limited evidence of carcinogenicity from human cancer studies. Numerous case reports have shown leukemia to occur following chloramphenicol-induced aplastic anemia (IARC 1990).
Why is chloramphenicol toxic?
The major toxicity of chloramphenicol is hematologic. In all vertebrates studied, it produces direct, dose-dependent bone marrow depression that results in reductions in red blood cells, white blood cells, and platelets in mammals.