Is sodium iodide Symporter present in pituitary?
The sodium-iodide symporter is most highly expressed in thyroid epithelial cells. Lower levels of expression can be detected in mammary gland, salivary gland, stomach and colon, but none of these tissues is known to organify iodide.
Is sodium iodide Symporter?
The sodium iodide symporter (NIS) is responsible for thyroidal, salivary, gastric, intestinal and mammary iodide uptake. It was first cloned from the rat in 1996 and shortly thereafter from human and mouse tissue. In the intervening years, we have learned a great deal about the biology of NIS.
Is iodine stored in the thyroid?
It is a trace element, just 5 gm of which are sufficient to meet the life-time needs of an individual with a life-span of 70 years(1). Iodine is mostly concentrated in thyroid gland(2). A healthy adult body contains 15-20 mg of iodine, 70-80% of which is stored in the thyroid gland.
What is sodium iodide used for?
What is sodium iodide? Sodium iodide is an iodide salt that is formed into an injectable medicine. Sodium iodide is used to treat or prevent iodine deficiency caused by poor nutrition or poor absorption by the body. Sodium iodide may also be used to treat a thyroid disorder.
Where are thyroid hormones synthesized?
Thyroid hormone biosynthesis occurs at the apical surface of polarized thyroid follicular cells and requires an intact synthesis pathway comprising transporter molecules, enzymes and thyroglobulin as well as adequate dietary iodide (Fig. 2).
Is T4 converted to T3?
T4 is converted into T3, the active form of thyroid hormone, by two enzymes called deiodinases. People with hypothyroidism are treated with a synthetic T4 hormone, which the enzymes convert to T3. This treatment is usually effective, but some people continue to have symptoms even after treatment.
What type of solid is sodium iodide?
Sodium iodide (chemical formula NaI) is an ionic compound formed from the chemical reaction of sodium metal and iodine. Under standard conditions, it is a white, water-soluble solid comprising a 1:1 mix of sodium cations (Na+) and iodide anions (I−) in a crystal lattice.
Where is iodine found?
Food Sources Iodine is found in soil and the ocean, which varies in amount and will affect how much of the mineral is contained in a food. Iodine is found mainly in animal protein foods and sea vegetables, and to a lesser extent in fortified foods like breads, cereals, and milk.
Where is sodium iodide found?
Iodine is found in various foods, including seafood, small amounts of iodized salt, and vegetables grown in iodine-rich soils.