What is the role of Oct4 in embryonic stem cells?
In the past several years, genome-wide identification of Oct4 target genes and Oct4-centered protein interactomes has been reported, indicating that Oct4 exerts tight control over pluripotency regulator expression and protects embryonic stem cells in an undifferentiated state.
Is Yap a transcription factor?
Yes-associated protein (YAP) is a potent transcription coactivator acting via binding to the TEAD transcription factor, and plays a critical role in organ size regulation. YAP is phosphorylated and inhibited by the Lats kinase, a key component of the Hippo tumor suppressor pathway.
What is Yap biology?
View/Edit Mouse. YAP1 (yes-associated protein 1), also known as YAP or YAP65, is a protein that acts as a transcriptional regulator by activating the transcription of genes involved in cell proliferation and suppressing apoptotic genes.
What is Oct4 biology?
Oct-4 is a homeodomain transcription factor of the POU family. It is critically involved in the self-renewal of undifferentiated embryonic stem cells. As such, it is frequently used as a marker for undifferentiated cells.
What is NANOG in biology?
NANOG is a transcription factor in embryonic stem cells (ESCs) and is thought to be a key factor in maintaining pluripotency. NANOG is thought to function in concert with other factors such as POU5F1 (Oct-4) and SOX2 to establish ESC identity.
How does Yap1 work?
Yap1 is a direct regulator of ROX1, which in turn represses FET4 [55]. Yap1 also plays an important role in arsenic compound detoxification by regulating genes encoding several of the cellular antioxidant defenses, important to mitigate arsenic-generated ROS [56].
What is a YAP marker?
The YAP marker originated when an Alu repetitive element retro transposed at the DYS 287 locus at location Yqll. The use of this polymorphic Alu insertion (PAI) in human. population studies has been bolstered by DNA sequenc.
What is TAZ and YAP?
YAP/TAZ are primary sensors of the cell’s physical nature, as defined by cell structure, shape and polarity. YAP/TAZ activation also reflects the cell “social” behavior, including cell adhesion and the mechanical signals that the cell receives from tissue architecture and surrounding extracellular matrix (ECM).
Is Oct4 a gene?
The Oct4 protein, encoded by the Pou5f1 gene was the very first master gene, discovered 25 years ago, to be absolutely required for the stemness properties of murine and primate embryonic stem cells.