What is the prognosis of follicular lymphoma?
The five-year survival rate for follicular lymphoma is between 80 and 90 percent, which means at least 80 to 90 percent of patients diagnosed with follicular lymphoma can live for at least five years after the diagnosis. Half of the patients diagnosed with this type of cancer can live for approximately 10 to 12 years.
What is the most important prognostic factor in Hodgkin’s lymphoma?
The presence of bulky mediastinal disease, high erythrocyte sedimentation rate (ESR), age, the number of lymph nodes involved, and the presence of extranodal disease are the major prognostic factors (6).
What is the Flipi score?
The original Follicular Lymphoma International Prognostic Index (FLIPI) was created from five clinicobiological features and defines low (0–1), intermediate (2), and high (3–5) risk groups with 5-year overall survival (OS) of 91%, 78%, and 53%, respectively2.
Can you survive follicular lymphoma?
The survival rate for follicular lymphoma at five years (that is, the percentage of patients who will be alive 5 years after diagnosis) is 80-90% and median survival is approximately 10-12 years. People with stage I follicular lymphoma may be able to be cured with radiation therapy.
How effective is Rituxan for lymphoma?
Rituximab with bendamustine (Treanda, Cephalon) was studied in a phase 2 trial in patients with relapsed disease. This combination was found to be very effective, with an ORR of 92%.
What is prognostic factor?
Listen to pronunciation. (prog-NOS-tik FAK-ter) A situation or condition, or a characteristic of a patient, that can be used to estimate the chance of recovery from a disease or the chance of the disease recurring (coming back).
What are the grades of follicular lymphoma?
Follicular lymphoma is usually slow growing and called a low grade lymphoma. Doctors might further subdivide follicular lymphoma into 3 grades. These are 1, 2, and 3. Grade 3 is divided into 3A and 3B.
How do you stage follicular lymphoma?
Staging Tests Tests to stage follicular lymphoma include blood tests, CT scans, and PET scans. Your doctor may also do a biopsy on a sample of tissue taken from a lymph node or your bone marrow. You may need surgery to remove a whole lymph node so doctors can examine it to stage your cancer.
Can I live 30 years with follicular lymphoma?
Follicular lymphoma is usually incurable but responds well to treatment. A person can live with follicular lymphoma for many years, even decades, after diagnosis.
Can you live 40 years with follicular lymphoma?
Lobetti-Bodoni et al18 studied 153 follicular lymphoma patients <40 years in comparison with 850 patients >40 years, and found that younger patients had longer overall survival and longer cause-specific survival.
What is the success rate of rituximab?
Is the follicular lymphoma International Prognostic Index useful?
The Follicular Lymphoma International Prognostic Index has become the clinically useful prognostic tool, but gives only a rough estimate of expected outcome. There is a need for useful biomarkers for prediction of the disease course of single patients to individualize therapy, especially in the new era of chemoimmunotherapy.
What is the prognosis of follicular lymphoma (FL)?
Follicular lymphoma (FL) is generally considered an indolent disorder. With modern day treatments, long remissions are often achieved both in the front-line and relapsed setting. However, a subset of patients has a more aggressive course and a worse outcome. Their identification is the main purpose of modern day prognostic tools.
What is follicular B cell lymphoma?
Follicular lymphoma (FL) is an indolent B-cell malignancy usually involving a lymph node with a morphologic appearance resembling follicular lymphoid structures. FL cells arise from germinal center B-cells of the lymphoid follicle (centrocytes and centroblasts) [1].
What is the most common pattern of lymphoma involvement?
The most frequent pattern of involvement is paratrabecular aggregates of lymphoma cells, with or without interstitial or diffuse patterns. The pure follicular (nodular) pattern in BM is present in about 5% of cases with BM involvement [40]. The liver and spleen are commonly involved in FL.