What is the function of MRP2?
The multi-drug resistance protein 2 (MRP2; ABCC2) is an ATP-binding cassette transporter playing an important role in detoxification and chemoprotection by transporting a wide range of compounds, especially conjugates of lipophilic substances with glutathione, glucuronate and sulfate, which are collectively known as …
What is MRP2 liver?
MRP2 is most highly expressed in the liver, where it facilitates the elimination of bilirubin glucuronides and positively charged drugs and conjugates into the bile. It plays a similar role in renal elimination, while in other organs such as the placenta and the GIT it restricts the distribution of its substrates.
Is defined as a method for the effective planning of all resources of a manufacturing company?
Manufacturing resource planning (MRP II) is defined as a method for the effective planning of all resources of a manufacturing company.
What drugs are P-gp substrates?
Examples of drugs that are substrates of P-gp efflux pump include: Apixaban, colchicine, cyclosporine, dabigatran, digoxin, edoxaban, rivaroxaban, and tacrolimus.
What is mrp1 and mrp2?
MRP I stands for material requirements planning, while MRP II stands for manufacturing resource planning. However, the terms are often used interchangeably.
How is manufacturing resources planning different from material requirements planning?
Material Requirement Planning is widely used approach for production planning and scheduling in industry….Difference between MRP and MRP II :
| MRP | MRP II |
|---|---|
| Stands for Material Requirements Planning. | Stands for Manufacturing Resource Planning. |
| Developed in 1970s. | Developed in 1980s. |
What is OATP1B1 substrate?
Summary. OATP1B1 is an uptake transporter exclusively expressed on the sinusoidal side of hepatocytes. It is responsible for the hepatic uptake of drugs and endogenous compounds from the blood. OATP1B1 substrates often, but by no means always, contain a carboxylic acid moiety.
What does OATP1B1 stand for?
OATP1B1
| Acronym | Definition |
|---|---|
| OATP1B1 | Organic Anion Transport Proteins 1b1 (transporter) |
What are cyp450 substrates?
substrates are drugs or other substances (xenobiotics) which are metabolized by cytochrome enzymes including 1. pharmacologically active drugs which require metabolism to inactive form for clearance from the body. metabolically activated drugs (prodrugs) which require conversion to active drug.