What is metronomic capecitabine?
Metronomic chemotherapy involves continuous administration of cytostatic drugs at low doses without longer drugfree intervals. Capecitabine (Xeloda) is a prodrug, given in a tablet formulation, that is selectively converted to 5-Fluorouracil at the tumor sites.
Is capecitabine used for liver cancer?
The most common side-effects of capecitabine were hand-foot syndrome and diarrhea. Conclusion: Capecitabine combined with TACE is safe and effective for advanced liver cancer.
What is the treatment of hepatocellular carcinoma?
Hepatocellular carcinoma treatments include: Surgery. Surgery to remove the cancer and a margin of healthy tissue that surrounds it may be an option for people with early-stage liver cancers who have normal liver function. Liver transplant surgery.
Is hepatocellular carcinoma treated with chemotherapy?
Abstract. Chemotherapy is one of the most important treatment modalities for advanced hepatocellular carcinoma (HCC). On the basis of the results of two pivotal Phase III placebo-controlled studies, sorafenib is currently acknowledged worldwide as the standard therapeutic agent for advanced HCC.
What does metronomic mean?
mechanically regular
Definition of metronomic 1 : mechanically regular (as in action or tempo) … the swimmer’s arms lift and glide under the surface in a reliable metronomic cadence …— Diana Nyad.
What is sequential metronomic chemotherapy?
Metronomic chemotherapy refers to the minimum biologically effective dose of a chemotherapy agent given as a continuous dosing regimen with no prolonged drug-free breaks that leads to antitumor activity.
How long can a liver cancer patient live?
Without treatment, the median survival for stage A liver cancer is 3 years. With treatment, between 50 and 70 out of 100 people (between 50 – 70%) will survive for 5 years or more.
Can liver cancer be cured completely?
If you have advanced liver cancer it might be very hard to treat. It may not be possible to cure the cancer. If this is the case, the aim of your treatment will be to limit the cancer and its symptoms, and help you live longer. Finding out the cancer cannot be cured can be very hard news to take in.
How quickly does HCC grow?
Question 5: how fast do tumors grow? The mean volume doubling time of small (,5 cm) HCCs ranges from 112 to 204 days; the interindividual variability of tumor growth is also very high, the individual doubling time ranging from 30 to 600 days (34–38).
How is metastatic HCC treated?
Treatment options for HCC are divided into surgical therapies (ie, resection, cryoablation, and liver transplantation) and nonsurgical therapies, which may be liver directed (ie, percutaneous ethanol injection, radiofrequency/microwave ablation, transarterial embolization, external beam radiation therapy) or systemic ( …