What is HomoloGene database?
HomoloGene: An Entrez Database with a New Look. HomoloGene is a system for automated detection of homologs among the annotated genes of several completely sequenced eukaryotic genomes. The genomes represented in the recent Build 36 of HomoloGene include H. sapiens, M. musculus, R.
What is the gene database and what is it used for?
A resource to provide a public, tracked record of reported relationships between human variation and observed health status with supporting evidence.
What are homologs orthologs and paralogs?
Orthologs are homologous genes in different species that diverged from a single ancestral gene after a speciation event and paralogs are homologous genes that originate from the intragenomic duplication of an ancestral gene.
How do you find homologs of a gene?
Search the HomoloGene database with the gene name. If you know both the gene symbol and organism, use a query such as this: tpo[gene name] AND human[orgn]. If your search finds multiple records, click on the desired record. The homologous genes are listed in the top of the report.
What is the difference between orthologs and paralogs?
“By definition, orthologs are genes that are related by vertical descent from a common ancestor and encode proteins with the same function in different species. By contrast, paralogs are homologous genes that have evolved by duplication and code for protein with similar, but not identical functions.”
What is PubMed used for?
PubMed is a free search engine accessing primarily the MEDLINE database of references and abstracts on life sciences and biomedical topics. The United States National Library of Medicine (NLM) at the National Institutes of Health maintain the database as part of the Entrez system of information retrieval.
What is Genome Database in bioinformatics?
The Genome Database (GDB, http://www.gdb.org ) is a public repository of data on human genes, clones, STSs, polymorphisms and maps. GDB entries are highly cross-linked to each other, to literature citations and to entries in other databases, including the sequence databases, OMIM, and the Mouse Genome Database.
Are all orthologs homologs?
Here, orthologs are defined as homologs in different species that catalyze the same reaction, and paralogs are defined as homologs in the same species that do not catalyze the same reaction.
What is the difference between homologous and homologs?
Homology forms the basis of organization for comparative biology. A homologous trait is often called a homolog (also spelled homologue). In genetics, the term “homolog” is used both to refer to a homologous protein and to the gene ( DNA sequence) encoding it.