What is atrophoderma of Pasini and Pierini?
Atrophoderma of Pasini and Pierini (APP) is a rare skin disorder affecting dermal collagen and presenting with dermal atrophy. The classic clinical manifestations of APP are hyperpigmented or hypopigmented, depressed areas of skin on the trunk or extremities (picture 1).
Can atrophoderma be cured?
There is no recognised treatment for atrophoderma of Pasini and Pierini. Cases associated with B burgdorferi antibodies may improve with doxycycline. Hydroxychloroquine and methotrexate have been reported to be co-incidentally effective in rare cases with associated disorders such as lupus erythematosus or psoriasis.
What is Pierini?
Atrophoderma of Pasini and Pierini (ATPP) is a rare skin condition that results in patchy areas of discolored skin. The main symptom of atrophoderma of Pasini and Pierini is multiple irregularly shaped, dark or light areas of skin in which the tissue under the skin breaks down resulting in a depression (dent).
How is Anetoderma treated?
Approach Considerations. To date, no effective treatment is available for anetoderma. Therapeutic options that have been used but have not shown consistent results include intralesional steroids, as well as systemic penicillin G, aspirin, phenytoin, dapsone, vitamin E, and niacin.
What is en coup de Sabre?
En coup de sabre (ECDS) is a rare form of localized scleroderma that typically manifests in children and women. It presents as a fibrous pansclerotic plaque extending in a bandlike distribution on the frontoparietal scalp with surrounding scarring alopecia.
What does Atrophoderma mean?
Atrophoderma refers to conditions involving skin atrophy.
What is bullous morphea?
Bullous morphea is a rare variant of localized scleroderma characterized by occasional intermittent blisters. Lichen sclerosus is a chronic inflammatory disease. The coexistence of morphea and lichen sclerosus has been reported in different sites in the same patient and more rarely in the same lesion.
What is generalized morphea?
Generalized morphea is defined as more than 4 indurated plaques larger than 3 cm each and/or involving 2 of more of 7 anatomic sites (head-neck, each extremity, anterior trunk, and posterior trunk) but sparing the face and hands.
What causes anetoderma?
Primary anetoderma is an idiopathic condition (meaning that we are not certain what factor(s) caused the skin to take on this type of appearance), while secondary anetoderma can be caused by certain infections, inflammatory conditions, tumors and other disease processes in the area of the skin lesions.
What is primary anetoderma?
Primary anetoderma is a rare idiopathic disease of the skin, characterized by circumscribed areas of loose skin, and loss of elastic fibers upon histopathologic examination. Two forms are traditionally distinguished, primary and secondary.
Is Parry-Romberg syndrome painful?
Parry-Romberg syndrome is also accompanied by neurological abnormalities including seizures and episodes of severe facial pain (trigeminal neuralgia). The onset of the disease usually begins between the ages of 5 and 15 years.