What is an individual patient level meta-analysis?
Individual patient data (IPD) MA are the gold standard of meta-analysis. In an IPD-MA line-by-line patient data are collected from the relevant studies, rather than just the measure of effect as in a standard aggregate data (AD) MA.
What is individual patient level data?
Individual participant data (also known as individual patient data, often abbreviated IPD) is raw data from individual participants, and is often used in the context of meta-analysis.
Can a single person perform a meta-analysis?
You need a minimum of TWO authors or you cannt complete various steps. You need 2 or more people to do each step of a systematic review like study selection or data extraction independently and then compare the results. Then any discrepancies can be discussed.
What is a study level meta-analysis?
Meta-analysis is a tool in the continual process of clinical research for the discovery of new knowledge and also a scientific basis for planning future research. Assessment of between-study heterogeneity is one of the prime values of meta-analysis from this standpoint (1,2).
What is the difference between Meta-Analyses and pooled analysis?
Unlike meta-analyses, pooled analyses can only be conducted if the included studies used the same study design and statistical models, and if their respective populations were homogeneous. If individual-level data from the included studies is available, the result of a pooled analysis can be considered more reliable.
What is a meta-analysis vs systematic review?
Systematic review or meta-analysis? A systematic review answers a defined research question by collecting and summarizing all empirical evidence that fits pre-specified eligibility criteria. A meta-analysis is the use of statistical methods to summarize the results of these studies.
What is individual data?
Collected data which can be associated with a single element in a sample are called individual data. An example: all data that result from responses from John Doe are individual data. The totality of all data collected in a survey is combined into aggregated data in order to be evaluated.
What is an aggregate data meta-analysis?
Purpose: A meta-analysis of aggregate data (AD) uses statistical analyses to generate a summary (pooled) estimate using effect estimates of individual studies reported in the published literature.
What is the difference between systematic review and meta-analysis?
Can a single author do a systematic review?
Systematic Reviews need to have more than one author in order to be considered “systematic”. A team can help cut down on bias, make judgment calls on allowing articles, and many journals will reject a study if it is labeled systematic review but only has one author.
What is an example of meta-analysis?
For example, if there are two groups of patients experiencing different treatment effects studies in two RCTs reporting conflicting results, the meta-analytic average is representative of neither group, similarly to averaging the weight of apples and oranges, which is neither accurate for apples nor oranges.
Is a post hoc analysis a systematic review?
You need a search protocol before starting a systematic review. You don’t, for a post-hoc study, but if the analysis leads to you to thinking of a clinical trial (based on your field), you will then of course, need to register your trial protocol.