What is a sterilizing cure?
Currently, two types of HIV cures are in development: a “sterilizing cure” and a “functional cure.” A sterilizing cure refers to the complete elimination of replication-competent proviruses in the body, while a functional cure refers to the long-term control of HIV replication without treatment.
How does HSV-1 enter a cell?
HSV has the ability to enter into host cells by direct fusion with the plasma membrane, or via endocytic pathways. The latter can be pH dependent or independent.
What cells does HSV-1 infect?
HSV-1 is a human alphaherpesvirus that initially replicates in epithelial cells of the oral and perioral mucosa. After entry into sensory neurons innervating these regions, the viral genomes are targeted to the neuronal nuclei, where they establish lifelong latent infections (11).
What cells does HSV-2 infect?
HSV-2 mainly infects epithelial cells and causes genital herpes. In addition to human cervical tissue and cervicovaginal epithelial cell lines, we performed experiments using primary human foreskin epithelial cells.
Is HSV-2 a DNA or RNA virus?
Herpes simplex virus (HSV) is a member of the Alphaherpesvirinae subfamily of the Herpesviridae family. HSV is a double-stranded DNA virus that infects a variety of host tissues and is characterized by a lytic and latent cycle.
What happens when HSV replicates?
The cellular replication cycle of HSV takes 4–12 hours, and HSV replication usually results in cell death. However, HSV replication does not cause cell death in some neuronal cells.
What are signs of HSV 1?
Symptoms
- Pain or itching. You may experience pain and tenderness in your genital area until the infection clears.
- Small red bumps or tiny white blisters. These may appear a few days to a few weeks after infection.
- Ulcers. These may form when blisters rupture and ooze or bleed.
- Scabs.