What happens during extravascular hemolysis?

What happens during extravascular hemolysis?

With extravascular hemolysis, the erythrocytes are degraded within macrophages (see image above), so hemoglobin is not released free into the cytoplasm. Thus, we do not see hemoglobinemia or hemoglobinuria with extravascular hemolysis alone, unless it is accompanied by intravascular hemolysis.

What are signs of extravascular hemolysis?

Extravascular hemolysis usually results from more subtle RBC destruction, typically with chronic splenic enlargement and jaundice. Extravascular hemolysis is more common with RBC membrane disorders such as hereditary spherocytosis. Some forms of hemolytic anemia feature both intravascular and extravascular hemolysis.

What happens to RBC in hemolysis?

Hemolysis is caused by the breakdown of the RBC, causing release of hemoglobin and resulting in the discoloration of the plasma.

What is the cause of extravascular hemolysis?

When large amounts of drug coat the cell surface, the antibody binds the cell membrane and causes extravascular hemolysis. Quinine-induced hemolysis is the prototype of the immune complex mechanism, in which the drug induces IgM antibody production.

Is Imha intravascular or extravascular?

IMHA may also be categorized based on whether it results in intravascular or extravascular hemolysis. Intravascular hemolysis results from the lysis of red blood cells by complement within the vasculature, and may be identified by the presence of free hemoglobin within the plasma and urine.

What is intrinsic and extrinsic hemolytic anemia?

Extrinsic: From a source outside the red cell; disorders extrinsic to the RBC are usually acquired. Intrinsic: Due to an defect within the red cell; intrinsic RBC abnormalities (see table Hemolytic Anemias. ) are usually inherited.

Is thalassemia an extravascular hemolysis?

Anemia is the most basic clinical characteristic of sickle cell disease and thalassemia. In sickle cell disease, the polymerization of sickle hemoglobin (HbS) causes profound changes in the integrity and viability of the erythrocyte, leading to both extravascular and intravascular hemolysis.

Is there jaundice in intravascular hemolysis?

In both forms of hemolysis, there is anemia and jaundice. Hemoglobinemia and hemoglobinuria occur only in intravascular hemolysis. Hypertrophy of the mononuclear phagocyte system and consequent splenomegaly are seen only in extravascular hemolysis.

Is IMHA intravascular or extravascular hemolysis?