What do Russell bodies indicate?
Russell bodies tend to be found in places with chronic inflammation. This is one cell variation found in multiple myeloma. Similar inclusion bodies that tend to overlie the nucleus or invaginate into are known as Dutcher bodies. They are named for William Russell (1852-1940), a Scottish physician.
What causes Mott cells?
Mott cells are associated with stress conditions occurring in a number of conditions including chronic inflammation, autoimmune diseases, lymphomas, multiple myeloma, and Wiskott–Aldrich syndrome.
What are Russell and Dutcher bodies?
Dutcher and Russell bodies are both intracytoplasmic spherical inclusions of the same origin, i.e. an accumulation of immunoglobulin (Eyre et al, 2014). They occur in neoplastic plasma or plasmacytoid cells, in multiple myeloma and also in other B-cell neoplasms.
What are the inclusions found in Russell bodies?
Russell bodies are multiple round cytoplasmic hyaline inclusions that are frequently seen in bone marrow aspirates in myeloma. They are composed of immunoglobulin molecules within vesicular structures derived from rough endoplasmic reticulum. Plasma cells containing them are sometimes referred to as Mott cells.
Where is Russell bodies found?
Russell bodies are considered to be aggregated unreleased immunoglobulin components, as a result of a block in the normal secretion pathway of immunoglobulins. They are stored within the rough endoplasmic reticulum of plasma cells and may totally fill up the cytoplasm and compress the nuclei.
Are plasma cells PAS positive?
Normal peripheral blood plasma cells are CD45+. In bone marrow, there are two subsets of plasma cells: one major subset positive for CD45 and a smaller negative one.
What is Mott cell?
Mott cells are plasma cells defective in immunoglobulin (Ig) secretion. They display this defect by accumulating Ig in the rough endoplasmic reticulum, detectable by Ig+ intracellular inclusion.
Where are Mott cells found?
Mott cells can be seen in plasma cell dyscrasias and reactive plasmacytoses such as chronic inflammatory conditions, autoimmune-mediated diseases (eg, Hashimoto’s thyroiditis and rheumatoid arthritis), and rare conditions like Wiskott-Aldrich syndrome and von Recklinghausen’s neurofibromatosis.
What is a Dutcher body?
Dutcher body (plural Dutcher bodies) (microbiology) One of the periodic acid-Schiff reaction-positive nuclear inclusions, containing immunoglobulin, that are either invaginated into or overlying the nucleus.
What are Kappa restricted plasma cells?
Plasma Cell Clonality: Plasma cell populations with a kappa to lambda ratio of either greater than 3.9 or less than 0.5 will be considered either kappa or lambda immunoglobulin light chain restricted (monotypic), respectively.
What is plasma cell dyscrasias?
Plasma cell dyscrasias are a monoclonal proliferation of plasma cells that produce a clonal immunoglobulin protein (i.e., monoclonal gammopathies or paraproteinemias). They are derived from malignant B lymphocytes. Common plasma cell dyscrasias include multiple myeloma and Waldenström’s macroglobulinemia.