What are the syndromes associated with cleft?
Sometimes when a child is born with a cleft lip and/or palate there is a chance that they may have additional medical condition/s. These associated conditions include ‘Pierre Robin Sequence’ (PRS), Stickler Syndrome and 22q11 Deletion Syndrome.
What syndromes are associated with cleft lip and palate?
Some of the conditions which may involve a cleft are:
- Pierre Robin sequence.
- Stickler syndrome.
- Velocardiofacial syndrome (VCF)
- Treacher Collins syndrome.
- Oculo-auriculo-vertebral spectrum (OAV) / Goldenhar syndrome / hemifacial microsomia.
- Van der Woude syndrome.
What is PRS syndrome?
Pierre Robin (Pee-air Roe-bahn) sequence, also called Pierre Robin syndrome, or PRS, is a condition where babies are born with a small lower jaw, have difficulties breathing (airway obstruction) and often (but not always) have a cleft of the palate (an opening in the roof of the mouth).
Can cleft be genetic?
Cleft lip and cleft palate are among the most common birth defects. They most commonly occur as isolated birth defects but are also associated with many inherited genetic conditions or syndromes.
Do you grow out of Pierre Robin Syndrome?
Most children with Pierre Robin Sequence grow up normally, even if they start their lives with quite severe problems. All babies with Pierre Robin Sequence will have some difficulties, but these will vary from child to child. Some have no problems with breathing and only minor feeding difficulties.
Are cleft palates hereditary?
The causes of cleft lip and cleft palate (or both) are unknown, although hereditary (genetic) factors sometimes play a small role. A cleft lip or cleft palate (or both) is not caused by anything the parents did or did not do during the pregnancy.
Is a cleft lip a genetic mutation?
Scientists find genetic mutation that causes cleft lip and palate, heart defects. Cleft lip and cleft palate are common birth defects affecting thousands of babies every year in the United States. New research uncovers the genetic mechanism behind these defects.