What are the markers of atherosclerosis?
The authors compared the value of 2 atherosclerosis markers (ankle-arm index (AAI) and aortic pulse wave velocity (aPWV)) and 3 inflammatory markers (C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α)) in predicting CHD events.
Why is apoE mouse model used in atherosclerosis research?
Atherosclerosis-prone apolipoprotein E-deficient (Apoe−/−) mice display poor lipoprotein clearance with subsequent accumulation of cholesterol ester-enriched particles in the blood, which promote the development of atherosclerotic plaques.
What is CRP gene?
CRP (C-Reactive Protein) is a Protein Coding gene. Diseases associated with CRP include Appendicitis and Acute Pyelonephritis. Among its related pathways are Activation of cAMP-Dependent PKA and Selenium Micronutrient Network.
Is atherosclerosis is an inflammatory disease?
Atherosclerosis is clearly an inflammatory disease and does not result simply from the accumulation of lipids.
Do mice get atherosclerosis?
Unlike humans, mice seldom develop atherosclerosis in the coronary arteries, but readily develop atherosclerosis in the aortic root. The much more rapid heart rate of the mouse and hence disturbed blood flow probably accounts for the atherosclerosis predilection at this site.
Do mice have LDL?
For example, they lack cholesteryl ester transfer protein (CETP),21 which shuttles cholesteryl esters from HDL to apoB-containing lipoproteins such as LDL and very low density lipoproteins (VLDL) in humans. Thus, mice carry the majority of plasma cholesterol in HDL22 while humans carry much of it in LDL.
Is atherosclerosis a genetic disease?
Atherosclerosis, the primary cause of coronary artery disease (CAD) and stroke, is a disorder with multiple genetic and environmental contributions. Genetic-epidemiologic studies have identified a surprisingly long list of genetic and nongenetic risk factors for CAD.